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• W2024056268 abstract "You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History I1 Apr 2015MP4-10 ONE OUT OF THREE INFERTILE MEN YOUNGER THAN 40 YEARS HAVE A TOTAL SERUM PSA VALUE GREATER THAN 1 NG/ML - FINDINGS OF A CROSS-SECTIONAL SURVEY IN WHITE-EUROPEAN MEN PRESENTING FOR COUPLE'S INFERTILITY Alessandro Serino, Paolo Capogrosso, Luca Boeri, Eugenio Ventimiglia, Giovanni La Croce, Giulia Castagna, Angela Pecoraro, Marco Paciotti, Silvia Ippolito, Roberta Scano, Rocco Damiano, Francesco Montorsi, and Andrea Salonia Alessandro SerinoAlessandro Serino More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Luca BoeriLuca Boeri More articles by this author , Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Giovanni La CroceGiovanni La Croce More articles by this author , Giulia CastagnaGiulia Castagna More articles by this author , Angela PecoraroAngela Pecoraro More articles by this author , Marco PaciottiMarco Paciotti More articles by this author , Silvia IppolitoSilvia Ippolito More articles by this author , Roberta ScanoRoberta Scano More articles by this author , Rocco DamianoRocco Damiano More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.153AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Previous data have suggested that infertile men have an increased risk of high-grade prostate cancer (PCa). In this context, male infertility may be considered an early and identifiable risk factor for the development of clinically significant PCa. We sought to assess serum PSA levels in men presenting for couples infertility, according to the EAU recommendation that a baseline serum PSA level should be obtained at 40–45 years of age (Heidenreich A, et al. Eur Urol 2013;64:347-54). METHODS Complete data from 403 consecutive men seeking medical help for couple's infertility were analyzed. Primary and secondary infertility were defined according to the World Health Organization (WHO) definition criteria. According to EAU recommendations, patients were stratified as younger (group 1) and older than 40 yrs (group 2). Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI; categorized 0 vs 1 vs ≥2). Testicular volume was assessed with a Prader orchidometer. Semen analysis values were assessed based on 2010 WHO reference criteria. Descriptive statistics and logistic regression models tested the association between potential predictors and total PSA levels. RESULTS Mean (SD; range) age was 36 [3.2 (21–40)] and 46.5 [5 (41–73)] in group 1 [n=198 (49.1%)] and group 2 [n=205 (50.9%)], respectively. Length of couple's infertility at first presentation was 27.7 (23.3; 12–204) and 31.3 (29.5; 12–280) months in group 1 and 2, respectively. Mean PSA levels were 0.93 ng/mL [0.6 (0.01-4.47)] and 0.96 ng/mL [1.2 (0.02-15.3)] in group 1 and group 2, respectively. Of group 1, 68 (34.3%) patients had serum PSA values >1 ng/mL. No differences were found in terms of age, BMI, CCI, testicular volumes, semen parameters, and rates of primary vs secondary infertility between patients of group 1 with PSA levels above vs below 1 ng/mL. At multivariate logistic regression analysis no clinical variables achieved independent predictive value for serum PSA >1 ng/mL in group 1. CONCLUSIONS These cross-sectional data showed that one out of three infertile men younger than 40 years have a total serum PSA value greater than 1 ng/mL. Current findings acquire significant clinical importance according to the EAU recommendations for early detection of PCa, which may reduce PCa-related mortality and reduce the risk of developing advanced and metastatic PCa. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e30 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Alessandro Serino More articles by this author Paolo Capogrosso More articles by this author Luca Boeri More articles by this author Eugenio Ventimiglia More articles by this author Giovanni La Croce More articles by this author Giulia Castagna More articles by this author Angela Pecoraro More articles by this author Marco Paciotti More articles by this author Silvia Ippolito More articles by this author Roberta Scano More articles by this author Rocco Damiano More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2024056268 title "MP4-10 ONE OUT OF THREE INFERTILE MEN YOUNGER THAN 40 YEARS HAVE A TOTAL SERUM PSA VALUE GREATER THAN 1 NG/ML - FINDINGS OF A CROSS-SECTIONAL SURVEY IN WHITE-EUROPEAN MEN PRESENTING FOR COUPLE'S INFERTILITY" @default.
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