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- W2024058512 abstract "The symptoms of Parkinson's disease (PD) can become increasingly difficult to control as the disease advances. l-dopa is the most efficacious therapy; however, with long-term therapy, motor and non-motor complications develop. There is now accumulating evidence that the progressive pathology of PD, the change in drug pharmaco-dynamics, and the pulsatile manner in which short-acting dopaminergic agents stimulate striatal dopamine receptors combine as key contributing factors to the priming of the basal ganglia for induction of motor complications. Dopamine receptor agonists have been extensively used as add-on therapy to l-dopa to treat motor complications. In this article we review the role of dopamine receptor agonists in the treatment of advanced parkinsonian patients." @default.
- W2024058512 created "2016-06-24" @default.
- W2024058512 creator A5031345514 @default.
- W2024058512 date "2009-12-01" @default.
- W2024058512 modified "2023-09-25" @default.
- W2024058512 title "Dopamine receptor agonists in the treatment of advanced Parkinson's disease" @default.
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- W2024058512 doi "https://doi.org/10.1016/s1353-8020(09)70836-3" @default.
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