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- W2024059336 abstract "The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts of both cancer biology and targeted cancer therapy. Currently, (1) sprouting angiogenesis, (2) vascular co-option, (3) vascular intussusception, (4) vasculogenic mimicry, (5) bone marrow-derived vasculogenesis, (6) cancer stem-like cell-derived vasculogenesis and (7) myeloid cell-driven angiogenesis are all considered to contribute to tumor angiogenesis. Many of these processes have been described in developmental angiogenesis; however, the relative contribution and relevance of these in human brain cancer remain unclear. Preclinical tumor models support a role for sprouting angiogenesis, vascular co-option and myeloid cell-derived angiogenesis in glioma vascularization, whereas a role for the other four mechanisms remains controversial and rather enigmatic. The anti-angiogenesis drug Avastin (Bevacizumab), which targets VEGF, has become one of the most popular cancer drugs in the world. Anti-angiogenic therapy may lead to vascular normalization and as such facilitate conventional cytotoxic chemotherapy. However, preclinical and clinical studies suggest that anti-VEGF therapy using bevacizumab may also lead to a pro-migratory phenotype in therapy resistant glioblastomas and thus actively promote tumor invasion and recurrent tumor growth. This review focusses on (1) mechanisms of tumor angiogenesis in human malignant glioma that are of particular relevance for targeted therapy and (2) controversial issues in tumor angiogenesis such as cancer stem-like cell-derived vasculogenesis and bone-marrow-derived vasculogenesis." @default.
- W2024059336 created "2016-06-24" @default.
- W2024059336 creator A5005964824 @default.
- W2024059336 creator A5073545313 @default.
- W2024059336 creator A5077149094 @default.
- W2024059336 date "2012-11-11" @default.
- W2024059336 modified "2023-10-14" @default.
- W2024059336 title "Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited" @default.
- W2024059336 cites W1516410466 @default.
- W2024059336 cites W1566059459 @default.
- W2024059336 cites W1579863504 @default.
- W2024059336 cites W1586697742 @default.
- W2024059336 cites W1671535089 @default.
- W2024059336 cites W1679229092 @default.
- W2024059336 cites W1778500358 @default.
- W2024059336 cites W1894493322 @default.
- W2024059336 cites W1901239216 @default.
- W2024059336 cites W1965162899 @default.
- W2024059336 cites W1965573954 @default.
- W2024059336 cites W1967600348 @default.
- W2024059336 cites W1968014316 @default.
- W2024059336 cites W1969328947 @default.
- W2024059336 cites W1973995705 @default.
- W2024059336 cites W1975777116 @default.
- W2024059336 cites W1978139448 @default.
- W2024059336 cites W1978148288 @default.
- W2024059336 cites W1980275866 @default.
- W2024059336 cites W1980725734 @default.
- W2024059336 cites W1982246723 @default.
- W2024059336 cites W1985317418 @default.
- W2024059336 cites W1986559037 @default.
- W2024059336 cites W1987606222 @default.
- W2024059336 cites W1992112921 @default.
- W2024059336 cites W2003022043 @default.
- W2024059336 cites W2004788508 @default.
- W2024059336 cites W2005374089 @default.
- W2024059336 cites W2006181509 @default.
- W2024059336 cites W2006202974 @default.
- W2024059336 cites W2012209116 @default.
- W2024059336 cites W2014339619 @default.
- W2024059336 cites W2014386715 @default.
- W2024059336 cites W2015344488 @default.
- W2024059336 cites W2017322644 @default.
- W2024059336 cites W2017668331 @default.
- W2024059336 cites W2020277172 @default.
- W2024059336 cites W2023164440 @default.
- W2024059336 cites W2025189992 @default.
- W2024059336 cites W2025370055 @default.
- W2024059336 cites W2026996188 @default.
- W2024059336 cites W2027179630 @default.
- W2024059336 cites W2029470215 @default.
- W2024059336 cites W2030370645 @default.
- W2024059336 cites W2033319153 @default.
- W2024059336 cites W2034400622 @default.
- W2024059336 cites W2034458870 @default.
- W2024059336 cites W2034697477 @default.
- W2024059336 cites W2036292414 @default.
- W2024059336 cites W2037196446 @default.
- W2024059336 cites W2039013742 @default.
- W2024059336 cites W2039844501 @default.
- W2024059336 cites W2045247659 @default.
- W2024059336 cites W2046220184 @default.
- W2024059336 cites W2046516822 @default.
- W2024059336 cites W2048306047 @default.
- W2024059336 cites W2053068006 @default.
- W2024059336 cites W2053155009 @default.
- W2024059336 cites W2053272214 @default.
- W2024059336 cites W2053375897 @default.
- W2024059336 cites W2053704719 @default.
- W2024059336 cites W2054633892 @default.
- W2024059336 cites W2059441259 @default.
- W2024059336 cites W2064982871 @default.
- W2024059336 cites W2066345054 @default.
- W2024059336 cites W2068499444 @default.
- W2024059336 cites W2069826874 @default.
- W2024059336 cites W2070412580 @default.
- W2024059336 cites W2070458377 @default.
- W2024059336 cites W2077238331 @default.
- W2024059336 cites W2077746894 @default.
- W2024059336 cites W2078326783 @default.
- W2024059336 cites W2078481843 @default.
- W2024059336 cites W2078766485 @default.
- W2024059336 cites W2080162976 @default.
- W2024059336 cites W2080196370 @default.
- W2024059336 cites W2084450090 @default.
- W2024059336 cites W2085292494 @default.
- W2024059336 cites W2085724817 @default.
- W2024059336 cites W2086919152 @default.
- W2024059336 cites W2093062161 @default.
- W2024059336 cites W2095002343 @default.
- W2024059336 cites W2096252516 @default.
- W2024059336 cites W2097387635 @default.
- W2024059336 cites W2098728140 @default.
- W2024059336 cites W2099196609 @default.
- W2024059336 cites W2100891986 @default.
- W2024059336 cites W2101332957 @default.
- W2024059336 cites W2101680696 @default.
- W2024059336 cites W2102055984 @default.