Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024062643> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2024062643 endingPage "247" @default.
- W2024062643 startingPage "241" @default.
- W2024062643 abstract "Abstract The electrochemical reduction of two 2-halogeno derivatives of 2′-deoxyadenosine, antileukemic agents (2-chloro-2′-deoxyadenosine (2-CldAdo) and 2-bromo-2t'-deoxyadenosine (2-BrdAdo)) and related ribosides (7-methyladenosine (m 7 Ado) and purine riboside (PR)) have been examined by d.c. and a.c. polarography as well as by macroelectrolysis. 2-CldAdo (Cladribine, Leustatin) undergoes a one-step reduction in very acidic medium, pH 1–3, while the reduction of 2-BrdAdo occurs in two steps in the pH range 1–6. Both 2-halogeno adenosines involve reduction of the C-halogen bond and the pyrimidine ring. The reduction products have been examined by UV and nuclear magnetic resonance spectroscopy and high performance liquid chromatography analysis and the reduction mechanism has been formulated. All investigated compounds including PR and m 7 Ado exhibit high surface activity confirmed by a.c. polarography. All investigated compounds and theirs reduction products were tested for inhibitory activity vs. Escherichia coli PNP with inosine as substrate and inhibition constants have been determined. 2-CldAdo and 2-BrdAdo, as well as the reduction products of 2-CldAdo and PR, were found to be good inhibitors of E. coli PNP, whereas the reduction products of m 7 Ado and 2′-deoxyadenosine do not bind to the enzyme." @default.
- W2024062643 created "2016-06-24" @default.
- W2024062643 creator A5020210972 @default.
- W2024062643 creator A5023423702 @default.
- W2024062643 creator A5046296870 @default.
- W2024062643 creator A5074710100 @default.
- W2024062643 creator A5080281122 @default.
- W2024062643 date "1996-03-01" @default.
- W2024062643 modified "2023-09-24" @default.
- W2024062643 title "Electrochemical and enzymatic study of 2-chloro-2′-deoxyadenosine (antileukemic agent) and related compounds" @default.
- W2024062643 cites W121485390 @default.
- W2024062643 cites W1637977129 @default.
- W2024062643 cites W1973559328 @default.
- W2024062643 cites W1984154752 @default.
- W2024062643 cites W1995570857 @default.
- W2024062643 cites W2000625604 @default.
- W2024062643 cites W2008734787 @default.
- W2024062643 cites W2011359837 @default.
- W2024062643 cites W2050846686 @default.
- W2024062643 cites W2056414768 @default.
- W2024062643 cites W2061528114 @default.
- W2024062643 cites W2069193976 @default.
- W2024062643 cites W2076825874 @default.
- W2024062643 cites W2086984633 @default.
- W2024062643 cites W2131277336 @default.
- W2024062643 cites W2330037949 @default.
- W2024062643 cites W2366820262 @default.
- W2024062643 cites W2418997373 @default.
- W2024062643 cites W2952738417 @default.
- W2024062643 cites W3021472025 @default.
- W2024062643 cites W4254179950 @default.
- W2024062643 cites W2042455903 @default.
- W2024062643 doi "https://doi.org/10.1016/0302-4598(95)01882-4" @default.
- W2024062643 hasPublicationYear "1996" @default.
- W2024062643 type Work @default.
- W2024062643 sameAs 2024062643 @default.
- W2024062643 citedByCount "4" @default.
- W2024062643 crossrefType "journal-article" @default.
- W2024062643 hasAuthorship W2024062643A5020210972 @default.
- W2024062643 hasAuthorship W2024062643A5023423702 @default.
- W2024062643 hasAuthorship W2024062643A5046296870 @default.
- W2024062643 hasAuthorship W2024062643A5074710100 @default.
- W2024062643 hasAuthorship W2024062643A5080281122 @default.
- W2024062643 hasConcept C147789679 @default.
- W2024062643 hasConcept C17525397 @default.
- W2024062643 hasConcept C181199279 @default.
- W2024062643 hasConcept C185592680 @default.
- W2024062643 hasConcept C21951064 @default.
- W2024062643 hasConcept C2780636463 @default.
- W2024062643 hasConcept C52859227 @default.
- W2024062643 hasConcept C55493867 @default.
- W2024062643 hasConceptScore W2024062643C147789679 @default.
- W2024062643 hasConceptScore W2024062643C17525397 @default.
- W2024062643 hasConceptScore W2024062643C181199279 @default.
- W2024062643 hasConceptScore W2024062643C185592680 @default.
- W2024062643 hasConceptScore W2024062643C21951064 @default.
- W2024062643 hasConceptScore W2024062643C2780636463 @default.
- W2024062643 hasConceptScore W2024062643C52859227 @default.
- W2024062643 hasConceptScore W2024062643C55493867 @default.
- W2024062643 hasIssue "2" @default.
- W2024062643 hasLocation W20240626431 @default.
- W2024062643 hasOpenAccess W2024062643 @default.
- W2024062643 hasPrimaryLocation W20240626431 @default.
- W2024062643 hasRelatedWork W1987674700 @default.
- W2024062643 hasRelatedWork W2027602243 @default.
- W2024062643 hasRelatedWork W2086912448 @default.
- W2024062643 hasRelatedWork W2087248011 @default.
- W2024062643 hasRelatedWork W2406618687 @default.
- W2024062643 hasRelatedWork W2953250471 @default.
- W2024062643 hasRelatedWork W3137452781 @default.
- W2024062643 hasRelatedWork W4239019398 @default.
- W2024062643 hasRelatedWork W4312052629 @default.
- W2024062643 hasRelatedWork W780397172 @default.
- W2024062643 hasVolume "39" @default.
- W2024062643 isParatext "false" @default.
- W2024062643 isRetracted "false" @default.
- W2024062643 magId "2024062643" @default.
- W2024062643 workType "article" @default.