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- W2024064022 abstract "alpha-crystallin is a molecular chaperone that maintains the optical properties of the lens and delays the onset scattering caused by aging-related protein aggregation. In this research, we found that the missense mutation R116H resulted in an altered size distribution, impaired packing of the secondary structures and modified quaternary structure with great hydrophobic exposure. The mutant exhibited a substrate-dependent chaperone (aggregation-inhibition) or anti-chaperone (aggregation-promotion) effect. Equilibrium unfolding experiments indicated that the mutation stabilized an aggregation-prone intermediate which was not populated during the unfolding of the wild-type protein. The accumulation of this intermediate greatly promoted the formation of non-native large oligomers or aggregates during unfolding. These results suggested that both the aggregation of the mutant upon stress and co-deposition with the target proteins were likely to be responsible for the onset of cataract." @default.
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- W2024064022 date "2010-04-01" @default.
- W2024064022 modified "2023-09-30" @default.
- W2024064022 title "Effects of congenital cataract mutation R116H on αA-crystallin structure, function and stability" @default.
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- W2024064022 doi "https://doi.org/10.1016/j.bbapap.2010.01.001" @default.
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