Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024064047> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2024064047 endingPage "154" @default.
- W2024064047 startingPage "154" @default.
- W2024064047 abstract "The toxicity of the mycotoxins nivalenol (NIV), deoxynivalenol (DON) and fumonisin B1 (FB1) were studied in the K562 human erythroleukemia cell line using the Trypan Blue, MTT and BrdU uptake analyses of cytotoxicity, cell metabolism and cell proliferation, respectively. Nuclear staining with propidium iodide and DNA analysis by flow cytometry were used to identify apoptosis and cell cycle distribution. By the MTT and BrdU tests, both NIV and DON were significantly more toxic than FB1 by at least one order of magnitude, with ID50s ranging from 0.5 μM for NIV to 70 μM for FB1. The MTT test indicated that NIV was significantly (approximately four times) more toxic than DON. In contrast, the Trypan Blue test did not reveal any effects of mycotoxin exposure suggesting that, at the concentrations tested, NIV, DON and FB1 did not induce cytotoxicity through plasma membrane damage. Cell cycle analysis suggested apoptotic cytotoxicity, revealing 100% cellular debris at the highest concentrations of NIV and DON and approximately 2.9 times more debris than control at the highest FB1 concentration. Morphological evidence of apoptosis was related to the toxicity of the substances, such that the more toxic NIV and DON resulted in more late stage apoptotic events than FB1. This study suggests that human blood cells are sensitive to mycotoxin exposure, that NIV is more toxic than DON which is more toxic than FB1, and that DNA damage and apoptosis rather than plasma membrane damage and necrosis may be responsible for the observed cytotoxicity." @default.
- W2024064047 created "2016-06-24" @default.
- W2024064047 creator A5001281235 @default.
- W2024064047 creator A5017999766 @default.
- W2024064047 creator A5026264544 @default.
- W2024064047 creator A5057053648 @default.
- W2024064047 creator A5057163354 @default.
- W2024064047 creator A5071513360 @default.
- W2024064047 creator A5085849450 @default.
- W2024064047 date "1998-07-01" @default.
- W2024064047 modified "2023-09-25" @default.
- W2024064047 title "Implication of lipid peroxidation in the cytotoxicity and genotoxicity of fumonisin B1" @default.
- W2024064047 doi "https://doi.org/10.1016/s0378-4274(98)80616-4" @default.
- W2024064047 hasPublicationYear "1998" @default.
- W2024064047 type Work @default.
- W2024064047 sameAs 2024064047 @default.
- W2024064047 citedByCount "2" @default.
- W2024064047 countsByYear W20240640472015 @default.
- W2024064047 crossrefType "journal-article" @default.
- W2024064047 hasAuthorship W2024064047A5001281235 @default.
- W2024064047 hasAuthorship W2024064047A5017999766 @default.
- W2024064047 hasAuthorship W2024064047A5026264544 @default.
- W2024064047 hasAuthorship W2024064047A5057053648 @default.
- W2024064047 hasAuthorship W2024064047A5057163354 @default.
- W2024064047 hasAuthorship W2024064047A5071513360 @default.
- W2024064047 hasAuthorship W2024064047A5085849450 @default.
- W2024064047 hasConcept C109316439 @default.
- W2024064047 hasConcept C143425029 @default.
- W2024064047 hasConcept C153911025 @default.
- W2024064047 hasConcept C178790620 @default.
- W2024064047 hasConcept C185592680 @default.
- W2024064047 hasConcept C190283241 @default.
- W2024064047 hasConcept C202751555 @default.
- W2024064047 hasConcept C2775934118 @default.
- W2024064047 hasConcept C2778959862 @default.
- W2024064047 hasConcept C2780070996 @default.
- W2024064047 hasConcept C2780358455 @default.
- W2024064047 hasConcept C2780783641 @default.
- W2024064047 hasConcept C2781429003 @default.
- W2024064047 hasConcept C2908803906 @default.
- W2024064047 hasConcept C29730261 @default.
- W2024064047 hasConcept C31573885 @default.
- W2024064047 hasConcept C31903555 @default.
- W2024064047 hasConcept C552990157 @default.
- W2024064047 hasConcept C55493867 @default.
- W2024064047 hasConcept C84699730 @default.
- W2024064047 hasConcept C86803240 @default.
- W2024064047 hasConceptScore W2024064047C109316439 @default.
- W2024064047 hasConceptScore W2024064047C143425029 @default.
- W2024064047 hasConceptScore W2024064047C153911025 @default.
- W2024064047 hasConceptScore W2024064047C178790620 @default.
- W2024064047 hasConceptScore W2024064047C185592680 @default.
- W2024064047 hasConceptScore W2024064047C190283241 @default.
- W2024064047 hasConceptScore W2024064047C202751555 @default.
- W2024064047 hasConceptScore W2024064047C2775934118 @default.
- W2024064047 hasConceptScore W2024064047C2778959862 @default.
- W2024064047 hasConceptScore W2024064047C2780070996 @default.
- W2024064047 hasConceptScore W2024064047C2780358455 @default.
- W2024064047 hasConceptScore W2024064047C2780783641 @default.
- W2024064047 hasConceptScore W2024064047C2781429003 @default.
- W2024064047 hasConceptScore W2024064047C2908803906 @default.
- W2024064047 hasConceptScore W2024064047C29730261 @default.
- W2024064047 hasConceptScore W2024064047C31573885 @default.
- W2024064047 hasConceptScore W2024064047C31903555 @default.
- W2024064047 hasConceptScore W2024064047C552990157 @default.
- W2024064047 hasConceptScore W2024064047C55493867 @default.
- W2024064047 hasConceptScore W2024064047C84699730 @default.
- W2024064047 hasConceptScore W2024064047C86803240 @default.
- W2024064047 hasLocation W20240640471 @default.
- W2024064047 hasOpenAccess W2024064047 @default.
- W2024064047 hasPrimaryLocation W20240640471 @default.
- W2024064047 hasRelatedWork W1970579504 @default.
- W2024064047 hasRelatedWork W1979153972 @default.
- W2024064047 hasRelatedWork W1982210364 @default.
- W2024064047 hasRelatedWork W2150258880 @default.
- W2024064047 hasRelatedWork W2153049241 @default.
- W2024064047 hasRelatedWork W2182837698 @default.
- W2024064047 hasRelatedWork W2337084509 @default.
- W2024064047 hasRelatedWork W2372646476 @default.
- W2024064047 hasRelatedWork W2943869068 @default.
- W2024064047 hasRelatedWork W4280525170 @default.
- W2024064047 hasVolume "95" @default.
- W2024064047 isParatext "false" @default.
- W2024064047 isRetracted "false" @default.
- W2024064047 magId "2024064047" @default.
- W2024064047 workType "article" @default.