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- W2024065582 abstract "Prostacyclin analogues have the potential to be effective agents in a new generation of drug-eluting stents by virtue of prostanoid IP receptor mediated anti-proliferative effects on smooth muscle cells. However, prostanoid IP receptor mediated vessel relaxation is reduced at elevated analogue concentrations. The mechanisms underlying this loss of activity are unclear, and its influence on the anti-proliferative potential of these compounds remains to be determined. A classical organ bath approach was used to examine the functional response of the rabbit iliac artery to the prostacyclin analogues, AFP-07 and cicaprost. Selective receptor antagonists for prostanoid IP (RO-1138452), EP1 (SC-51322) and EP3 (L-798106) receptors were used to characterise the receptors involved. The effects of these agents on proliferation ([3H]-thymidine incorporation) of rabbit iliac artery smooth muscle cells stimulated by foetal calf serum were then studied. AFP-07 gave a bell-shaped log concentration–response curve consisting of prostanoid IP receptor mediated relaxation followed by reversal at higher concentrations. SC-51322 and L-798106 potentiated this relaxation, although only L-798106 completely removed the contractile element. The prostanoid EP3 receptor agonist, sulprostone, produced constriction, which was attenuated by L-798106. RO-1138452 blocked the inhibitory action of AFP-07 and cicaprost on proliferation, implicating an involvement of prostanoid IP receptors. L-798106 had no effect on the anti-proliferative effect of cicaprost, but reduced the effect of AFP-07. Non-selective activation of prostanoid EP3 receptors (and possibly prostanoid EP1 receptors) compromises the relaxant activity of prostacyclin analogues, although it does not reduce the anti-proliferative capacity of these compounds in the model studied." @default.
- W2024065582 created "2016-06-24" @default.
- W2024065582 creator A5079778615 @default.
- W2024065582 creator A5084299646 @default.
- W2024065582 creator A5025862674 @default.
- W2024065582 date "1986-01-01" @default.
- W2024065582 modified "2023-09-29" @default.
- W2024065582 title "Suppression of principal atherosclerotic mechanisms by prostacyclinc and other eicosanoids" @default.
- W2024065582 cites W1519494647 @default.
- W2024065582 cites W1529154217 @default.
- W2024065582 cites W1532896263 @default.
- W2024065582 cites W1534180127 @default.
- W2024065582 cites W1543020414 @default.
- W2024065582 cites W1543283875 @default.
- W2024065582 cites W1564613206 @default.
- W2024065582 cites W1595467693 @default.
- W2024065582 cites W1605653259 @default.
- W2024065582 cites W174675987 @default.
- W2024065582 cites W1902852842 @default.
- W2024065582 cites W1947925671 @default.
- W2024065582 cites W1948783477 @default.
- W2024065582 cites W1963842597 @default.
- W2024065582 cites W1964390699 @default.
- W2024065582 cites W1969575905 @default.
- W2024065582 cites W1972664321 @default.
- W2024065582 cites W1977644543 @default.
- W2024065582 cites W1979352847 @default.
- W2024065582 cites W1980197284 @default.
- W2024065582 cites W1980244877 @default.
- W2024065582 cites W1981624220 @default.
- W2024065582 cites W1983041452 @default.
- W2024065582 cites W1986111942 @default.
- W2024065582 cites W1988293686 @default.
- W2024065582 cites W1990422782 @default.
- W2024065582 cites W1991461549 @default.
- W2024065582 cites W1991619890 @default.
- W2024065582 cites W1992309287 @default.
- W2024065582 cites W1994967652 @default.
- W2024065582 cites W1996219304 @default.
- W2024065582 cites W2000013500 @default.
- W2024065582 cites W2001247678 @default.
- W2024065582 cites W2001927761 @default.
- W2024065582 cites W2002032300 @default.
- W2024065582 cites W2002360032 @default.
- W2024065582 cites W2004195893 @default.
- W2024065582 cites W2010939527 @default.
- W2024065582 cites W2012281033 @default.
- W2024065582 cites W2013158870 @default.
- W2024065582 cites W2019249025 @default.
- W2024065582 cites W2019422408 @default.
- W2024065582 cites W2022042076 @default.
- W2024065582 cites W2022248411 @default.
- W2024065582 cites W2023846584 @default.
- W2024065582 cites W2026008999 @default.
- W2024065582 cites W2026937460 @default.
- W2024065582 cites W2028478753 @default.
- W2024065582 cites W2034371869 @default.
- W2024065582 cites W2036829084 @default.
- W2024065582 cites W2037038240 @default.
- W2024065582 cites W2039916130 @default.
- W2024065582 cites W2041471457 @default.
- W2024065582 cites W2041521801 @default.
- W2024065582 cites W2042819132 @default.
- W2024065582 cites W2047431516 @default.
- W2024065582 cites W2049139840 @default.
- W2024065582 cites W2050795431 @default.
- W2024065582 cites W2051105453 @default.
- W2024065582 cites W2053174844 @default.
- W2024065582 cites W2053235682 @default.
- W2024065582 cites W2054605326 @default.
- W2024065582 cites W2054631446 @default.
- W2024065582 cites W2055184058 @default.
- W2024065582 cites W2055366835 @default.
- W2024065582 cites W2055992597 @default.
- W2024065582 cites W2056782934 @default.
- W2024065582 cites W2058440862 @default.
- W2024065582 cites W2059014753 @default.
- W2024065582 cites W2059207702 @default.
- W2024065582 cites W2059915925 @default.
- W2024065582 cites W2061607137 @default.
- W2024065582 cites W2062247065 @default.
- W2024065582 cites W2068345870 @default.
- W2024065582 cites W2070459359 @default.
- W2024065582 cites W2077615283 @default.
- W2024065582 cites W2078406520 @default.
- W2024065582 cites W2080678890 @default.
- W2024065582 cites W2081125741 @default.
- W2024065582 cites W2081622052 @default.
- W2024065582 cites W2081994742 @default.
- W2024065582 cites W2082176634 @default.
- W2024065582 cites W2082672996 @default.
- W2024065582 cites W2087186913 @default.
- W2024065582 cites W2088218365 @default.
- W2024065582 cites W2088580000 @default.
- W2024065582 cites W2091161936 @default.
- W2024065582 cites W2092396725 @default.
- W2024065582 cites W2092447468 @default.
- W2024065582 cites W2093927588 @default.