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• W2024065918 abstract "The purpose of this study is to investigate the inhibitory effect of a glycoprotein (CTB glycoprotein, 75 kDa) isolated from Cudrania tricuspidata Bureau (CTB) on the di-(2-ethylhexyl)phthalate (DEHP) induced expression of allergic-inflammation-related mediators in human mast cells. The changes on the levels of intracellular reactive oxygen species (ROS), mitogen-activated protein kinase (MAPK), transcription factor [nuclear factor (NF)-κB], and allergic inflammatory mediators [cyclooxygenase (COX)-2 and interleukin (IL)-1β] were evaluated using Western blot and RT-PCR. Our results showed that the CTB glycoprotein in the presence of DEHP inhibits the production of intracellular ROS, the phosphorylation of ERK1/2, and p38 MAPK in HMC-1 cells. In addition, the CTB glycoprotein has suppressive effects on the transcriptional activation of NF-κB, and on the expression levels of COX-2 and IL-1β in DEHP-treated HMC-1 cells. In conclusion, the CTB glycoprotein has a strong anti-inflammatory effect on the activities of allergic inflammatory mediators indirectly caused by DEHP in HMC-1 cells. Copyright © 2010 John Wiley & Sons, Ltd." @default.
• W2024065918 created "2016-06-24" @default.
• W2024065918 creator A5043921996 @default.
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• W2024065918 date "2010-06-04" @default.
• W2024065918 modified "2023-09-25" @default.
• W2024065918 title "Phytoglycoprotein (75 kDa) inhibits expression of interleukin-1β stimulated by DEHP in human mast cells" @default.
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• W2024065918 doi "https://doi.org/10.1002/cbf.1648" @default.
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