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- W2024066451 abstract "The early mechanism of hCG induced down regulation of its own receptor as well as steroidogenesis refractoriness of rat Leydig cells to gonadotropin stimulation have been investigated. A single injection of 5, 12, 25, 50 and 100 IU of hCG in rats induced within 8 hours, Leydig cells desensitization. However, apparent receptor loss was significantly lower only in the rats who received 50 and 100 IU of hCG. Cycloheximide inhibits hCG-induced receptors loss but had no effect on hCG-induced desensitization. The most likely explanation for desensitization in the presence of binding sites and a normal adenylate cyclase, is a defective coupling between the receptor sites and the catalytic subunit." @default.
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- W2024066451 date "1978-03-01" @default.
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- W2024066451 title "Early hCG-induced desensitization in Leydig cells" @default.
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- W2024066451 doi "https://doi.org/10.1016/0006-291x(78)91570-x" @default.
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