FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024073478> ?p ?o ?g. }

• W2024073478 endingPage "791" @default.
• W2024073478 startingPage "781" @default.
• W2024073478 abstract "Association between staphylococcal infection and pathogenesis of upper airways disease has been reported. This study aimed to investigate the mechanisms underlying the rat pulmonary inflammation induced by airway exposure to staphylococcal enterotoxin A (SEA). SEA (0.3-10 ng trachea(-1)) caused dose-dependent neutrophil accumulation in BAL fluid, reaching maximal responses at 4 h (25-fold increase for 3 ng trachea(-1)). Significant accumulation of both lymphocytes and macrophages in BAL fluid was also observed at 4 h (2.1- and 1.9-fold increase, respectively, for 3 ng trachea(-1)). At later times (16 h), neutrophil counts in bone marrow (immature forms) and peripheral blood increased by 63 and 81%, respectively. SEA failed to directly induce chemotaxis and adhesion of isolated neutrophils. Analysis of mRNA expression for iNOS, COX-2 and CINC-2 in lung tissue showed an upregulation of these enzymes, which paralleled elevated levels of LTB4, PGE2, TNF-alpha, IL-6 and NO2- in BAL fluid. Expression of CINC-1 was unchanged, whereas CINC-3 was reduced in SEA-treated rats. Incubation of isolated alveolar macrophages with SEA (3 microg ml(-1)) resulted in significant elevations of TNF-alpha and NO2- levels in the cell supernatants. Dexamethasone (0.5 mg kg(-1)), celecoxib (3 mg kg(-1)) and compound 1400 W (5 mg kg(-1)) markedly reduced SEA-induced lung neutrophil influx and NO2- levels in BAL fluid. The lipoxygenase inhibitor AA-861 (100 microg kg(-1)) partly inhibited the neutrophil influx in SEA-treated rats without modifying the NO2- levels. None of these treatments reduced the number of mononuclear cells in BAL fluid (except of dexamethasone, which abolished the increased lymphocyte counts). Our study shows that airways exposure to SEA results in marked neutrophil influx through mechanisms involving increased expressions of CINC-2, iNOS and COX-2, as well as enhanced production of NO, PGE2, LTB4, TNF-alpha and IL-6." @default.
• W2024073478 created "2016-06-24" @default.
• W2024073478 creator A5012629720 @default.
• W2024073478 creator A5022015826 @default.
• W2024073478 creator A5032661283 @default.
• W2024073478 creator A5041617090 @default.
• W2024073478 creator A5055807719 @default.
• W2024073478 creator A5060879543 @default.
• W2024073478 creator A5072288857 @default.
• W2024073478 creator A5076700857 @default.
• W2024073478 date "2005-11-01" @default.
• W2024073478 modified "2023-10-14" @default.
• W2024073478 title "Inflammatory mechanisms underlying the rat pulmonary neutrophil influx induced by airway exposure to staphylococcal enterotoxin type A" @default.
• W2024073478 cites W1515133375 @default.
• W2024073478 cites W1562855996 @default.
• W2024073478 cites W1577594479 @default.
• W2024073478 cites W1597890140 @default.
• W2024073478 cites W1832498930 @default.
• W2024073478 cites W1952386736 @default.
• W2024073478 cites W1964979213 @default.
• W2024073478 cites W1968245239 @default.
• W2024073478 cites W1974797000 @default.
• W2024073478 cites W1982032265 @default.
• W2024073478 cites W1991203226 @default.
• W2024073478 cites W1993136590 @default.
• W2024073478 cites W1993997407 @default.
• W2024073478 cites W1998507628 @default.
• W2024073478 cites W2010277922 @default.
• W2024073478 cites W2016415261 @default.
• W2024073478 cites W2020358486 @default.
• W2024073478 cites W2024733558 @default.
• W2024073478 cites W2027752681 @default.
• W2024073478 cites W2035516341 @default.
• W2024073478 cites W2035525902 @default.
• W2024073478 cites W2035695365 @default.
• W2024073478 cites W2038127600 @default.
• W2024073478 cites W2040389813 @default.
• W2024073478 cites W2047359372 @default.
• W2024073478 cites W2047882502 @default.
• W2024073478 cites W2048931132 @default.
• W2024073478 cites W2054519973 @default.
• W2024073478 cites W2058816283 @default.
• W2024073478 cites W2061247847 @default.
• W2024073478 cites W2063732587 @default.
• W2024073478 cites W2063960126 @default.
• W2024073478 cites W2065707567 @default.
• W2024073478 cites W2068749033 @default.
• W2024073478 cites W2080629544 @default.
• W2024073478 cites W2084827879 @default.
• W2024073478 cites W2085241425 @default.
• W2024073478 cites W2086417745 @default.
• W2024073478 cites W2088235704 @default.
• W2024073478 cites W2097681404 @default.
• W2024073478 cites W2098829747 @default.
• W2024073478 cites W2141899922 @default.
• W2024073478 cites W2143176206 @default.
• W2024073478 cites W2152833994 @default.
• W2024073478 cites W2160223152 @default.
• W2024073478 cites W2160232295 @default.
• W2024073478 cites W2162428378 @default.
• W2024073478 cites W2169167040 @default.
• W2024073478 cites W2278769340 @default.
• W2024073478 cites W2314649741 @default.
• W2024073478 cites W3188209924 @default.
• W2024073478 cites W4313331917 @default.
• W2024073478 cites W4313333830 @default.
• W2024073478 cites W75858226 @default.
• W2024073478 doi "https://doi.org/10.1038/sj.bjp.0706393" @default.
• W2024073478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1751208" @default.
• W2024073478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16170330" @default.
• W2024073478 hasPublicationYear "2005" @default.
• W2024073478 type Work @default.
• W2024073478 sameAs 2024073478 @default.
• W2024073478 citedByCount "30" @default.
• W2024073478 countsByYear W20240734782012 @default.
• W2024073478 countsByYear W20240734782013 @default.
• W2024073478 countsByYear W20240734782014 @default.
• W2024073478 countsByYear W20240734782015 @default.
• W2024073478 countsByYear W20240734782016 @default.
• W2024073478 countsByYear W20240734782017 @default.
• W2024073478 countsByYear W20240734782019 @default.
• W2024073478 countsByYear W20240734782020 @default.
• W2024073478 countsByYear W20240734782021 @default.
• W2024073478 countsByYear W20240734782023 @default.
• W2024073478 crossrefType "journal-article" @default.
• W2024073478 hasAuthorship W2024073478A5012629720 @default.
• W2024073478 hasAuthorship W2024073478A5022015826 @default.
• W2024073478 hasAuthorship W2024073478A5032661283 @default.
• W2024073478 hasAuthorship W2024073478A5041617090 @default.
• W2024073478 hasAuthorship W2024073478A5055807719 @default.
• W2024073478 hasAuthorship W2024073478A5060879543 @default.
• W2024073478 hasAuthorship W2024073478A5072288857 @default.
• W2024073478 hasAuthorship W2024073478A5076700857 @default.
• W2024073478 hasBestOaLocation W20240734781 @default.
• W2024073478 hasConcept C126322002 @default.
• W2024073478 hasConcept C134018914 @default.
• W2024073478 hasConcept C185592680 @default.
• W2024073478 hasConcept C198677920 @default.

• next