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- W2024073755 abstract "Echocardiograms (E) were obtained from 44 children with SS and from 54 normal Blacks (Nl). Equations for predicting the normal values (PN) for 12 echo parameters were derived (PN = A . BSAb . HRc ± K), and the observed values from SS then expressed as standard deviation from normal (O PN). Increased cardiac output, LVEDD, LVESD, wall thickness, LAmax and Ao diameter were observed in SS (p < 0.001); however, the functional parameters %MAS, VCF and PEP/ET did not differ from Nl. Density function curves (DFC), derived by discriminant regression analysis using 7 echo parameters were obtained with equation: Ydv = K1 OPN1 + K2 OPN2 + Kn OPNn ± X, where Ydv = discriminating value and K, X = constants. There was clear separation of the DFC of SS and Nl. Eleven children with SS underwent hypertransfusion therapy (HT) for 3/12-3 yrs (packed RBC q 2-3 weeks) to achieve Hgb ≥ 10 gm %, % S Hgb < 20%. E were obtained periodically before/after, and during HT. Mean values during HT/off HT were: Hgb 9.7/7.2 (p < .001), % S Hgb 12.1/88.2 (p < .001). The DFC and Ydv before and after HT did not differ from those of 44 untreated SS (P = NS); during HT, there was significant shift (p < 0.001) of DFC and Ydv towards Nl. We conclude that cardiac size and function are abnormal in SS children, improve during HT, but revert back to abnormal state after discontinuing the HT." @default.
- W2024073755 created "2016-06-24" @default.
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- W2024073755 date "1981-04-01" @default.
- W2024073755 modified "2023-09-23" @default.
- W2024073755 title "199 CARDIAC STATUS OF CHILDREN WITH SICKLE CELL ANEMIA (SS)" @default.
- W2024073755 doi "https://doi.org/10.1203/00006450-198104001-00208" @default.
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