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- W2024074932 abstract "The effect of isoproterenol (1 to 9 μg) administered intravenously within 30 to 90 seconds was studied in 106 patients with abnormal negative T waves. T waves remained abnormal in patients with QRS >- 0.10 second and in patients with myocardial infarction or pericarditis. T wave abnormality was reversed in 96 percent of patients with QRS < 0.10 second. The reversal occurred in patients with and without heart disease, and usually coincided with an increase in heart rate by an average of 34 beats/min. However, in most patients, the same increase in heart rate produced by atropine or atrial pacing failed to reverse the abnormal T wave. Isoproterenol shortened the Q-T interval by an average of 20 msec more than atropine, and the reversal of T wave abnormalities was associated with the combination of a critical increase in heart rate and a critical decrease in Q-T interval. The Q-T interval shortening was significantly less in patients with myocardial infarction and pericarditis than in all other patients. Isoproterenol did not change the QRS complex, and the effect of the drug on the T wave was attributed to unequal shortening of repolarization in different areas of myocardium. Our results suggest that the rapid infusion of small quantities of isoproterenol may be useful in separating T wave abnormalities due to myocardial infarction or pericarditis from other primary abnormalities." @default.
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- W2024074932 date "1972-12-01" @default.
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- W2024074932 title "Effect of isoproterenol on the abnormal T wave" @default.
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- W2024074932 doi "https://doi.org/10.1016/0002-9149(72)90004-5" @default.
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