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- W2024079683 abstract "Triphasic oral contraceptive (Logynon) induced a significant increase (36%) in the maximal binding capacity of platelet membranes for [3H]imipramine. The increase was achieved in the second Logynon cycle as compared to pretreatment and first Logynon cycle binding values. The pill contains a combination of ethinyl estradiol and levonorgestrel, and it is as yet unclear which of the two hormones is responsible for the up-regulatory effect. The increase in the density of platelet imipramine binding sites may reflect a similar alteration in brain. The increase in imipramine binding did not correlate with alteration in mood as assessed by Beck Depression Inventory scores.As an indicator of analogous brain serotonin metabolism, and by extension of depression tendency, platelet imipramine receptors were measured in women taking the triphasic oral contraceptive Logynon. Logynon (Schering AG Berlin/Bergkamen, Germany) contains levonorgestrel 50 mcg for 6 days, 75 mcg for 5 days and 125 mcg for 10 days, followed by 7 days pill-free; ethinyl estradiol doses are 30, 40 and 30 mcg for the same periods of time. The mean imipramine binding values (Bmax), calculated from Scatchard plots of tritiated uptake by platelets, was 429 in the control cycle, 396 on Day 14 of the 1st treatment cycle, and 582 in the 2nd treatment cycle (p0.02 vs pretreatment). Control means were 412 and 411. No significant differences were seen in affinity (Kd). There were no significant differences in mean Beck Depression Inventory tests, although 1 woman became clinically depressed, with BDI scores of 22 and 33 compared to 2 before taking Logynon. Her Bmax values were 626, 630 and 796 in the pretreatment, 1st and 2nd cycles respectively. Overall, the increase in imipramine binding did not correlate with Beck depression inventory scores." @default.
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- W2024079683 date "1988-01-01" @default.
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- W2024079683 title "Up-regulatory effect of triphasic oral contraceptive on platelet 3H-imipramine binding sites" @default.
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- W2024079683 doi "https://doi.org/10.1016/0165-1781(88)90031-5" @default.
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