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• W2024084918 abstract "Development of a comprehensive therapeutic treatment for the neurodegenerative Alzheimer's disease (AD) is limited by our understanding of the underlying biochemical mechanisms that drive neuronal failure. Numerous dysfunctional mechanisms have been described in AD, ranging from protein aggregation and oxidative stress to biometal dyshomeostasis and mitochondrial failure. In this review we discuss the critical role of amyloid-β (Aβ) in some of these potential mechanisms of neurodegeneration. The 39–43 amino acid Aβ peptide has attracted intense research focus since it was identified as a major constituent of the amyloid deposits that characterise the AD brain, and it is now widely recognised as central to the development of AD. Familial forms of AD involve mutations that lead directly to altered Aβ production from the amyloid-β A4 precursor protein, and the degree of AD severity correlates with specific pools of Aβ within the brain. Aβ contributes directly to oxidative stress, mitochondrial dysfunction, impaired synaptic transmission, the disruption of membrane integrity, and impaired axonal transport. Further study of the mechanisms of Aβ mediated neurodegeneration will considerably improve our understanding of AD, and may provide fundamental insights needed for the development of more effective therapeutic strategies." @default.
• W2024084918 created "2016-06-24" @default.
• W2024084918 creator A5002938041 @default.
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• W2024084918 creator A5047385288 @default.
• W2024084918 date "2008-01-01" @default.
• W2024084918 modified "2023-09-27" @default.
• W2024084918 title "Mechanisms of Aβ mediated neurodegeneration in Alzheimer's disease" @default.
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