FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024085735> ?p ?o ?g. }

• W2024085735 endingPage "3461" @default.
• W2024085735 startingPage "3451" @default.
• W2024085735 abstract "During ischaemia neurons depolarize and release the neurotransmitter L-glutamate, which accumulates extracellularly and binds to postsynaptic receptors. This initiates a sequence of events thought to culminate in immediate and delayed neuronal death. However, there is growing evidence that during ischaemia the development of spreading depression (SD) can be an important determinant of the degree and extent of ischaemic damage. In contrast, SD without metabolic compromise (as occurs in migraine aura) causes no discernible damage to brain tissue. SD is a profound depolarization of neurons and glia that propagates like a wave across brain tissue. Brain cell swelling, an early event of both the excitotoxic process and of SD, can be assessed by imaging associated intrinsic optical signals (IOSs). We demonstrate here that IOS imaging clearly demarcates the ignition site and migration of SD across the submerged hippocampal slice of the rat. If SD is induced by elevating [K+]O, the tissue fully recovers, but in slices that are metabolically compromised at 37.5 degrees C by oxygen/glucose deprivation (OGD) or by ouabain exposure, cellular damage develops only where SD has propagated. Specifically, the evoked CA1 field potential is permanently lost, the cell bodies of involved neurons swell and their dendritic regions increase in opacity. In contrast to OGD, bath application of L-glutamate (6-10 mM) at 37.5 degrees C evokes a non-propagating LT increase in CA1 that reverses without obvious cellular damage. Moreover, application of 2-20 mM glutamate or various glutamate agonists fail to evoke SD in the submerged hippocampal slice. We propose that SD and OGD together (but not alone) constitute a 'one-two punch', causing acute neuronal death in the slice that is not replicated by elevated glutamate. These findings support the proposal that SD generation during stroke promotes and extends acute ischaemic damage." @default.
• W2024085735 created "2016-06-24" @default.
• W2024085735 creator A5041699483 @default.
• W2024085735 creator A5087468075 @default.
• W2024085735 date "1998-11-01" @default.
• W2024085735 modified "2023-10-18" @default.
• W2024085735 title "<b>Spreading depression determines acute cellular damage in the hippocampal slice during oxygen/glucose deprivation</b>" @default.
• W2024085735 cites W133907179 @default.
• W2024085735 cites W1937363507 @default.
• W2024085735 cites W1941392759 @default.
• W2024085735 cites W1966948445 @default.
• W2024085735 cites W1968305429 @default.
• W2024085735 cites W1975850619 @default.
• W2024085735 cites W1975934006 @default.
• W2024085735 cites W1979668799 @default.
• W2024085735 cites W1980723823 @default.
• W2024085735 cites W1981855711 @default.
• W2024085735 cites W1982395498 @default.
• W2024085735 cites W1982892406 @default.
• W2024085735 cites W1986026788 @default.
• W2024085735 cites W1987289297 @default.
• W2024085735 cites W1992026104 @default.
• W2024085735 cites W1994638214 @default.
• W2024085735 cites W1994907910 @default.
• W2024085735 cites W1996057550 @default.
• W2024085735 cites W1998969072 @default.
• W2024085735 cites W2006904109 @default.
• W2024085735 cites W2020922795 @default.
• W2024085735 cites W2023402127 @default.
• W2024085735 cites W2035403307 @default.
• W2024085735 cites W2048533614 @default.
• W2024085735 cites W2051143596 @default.
• W2024085735 cites W2055668062 @default.
• W2024085735 cites W2063434151 @default.
• W2024085735 cites W2064158371 @default.
• W2024085735 cites W2066774202 @default.
• W2024085735 cites W2071258611 @default.
• W2024085735 cites W2075473660 @default.
• W2024085735 cites W2076878418 @default.
• W2024085735 cites W2088023851 @default.
• W2024085735 cites W2104592058 @default.
• W2024085735 cites W2105826342 @default.
• W2024085735 cites W2117807828 @default.
• W2024085735 cites W2122930160 @default.
• W2024085735 cites W2128744963 @default.
• W2024085735 cites W2129633872 @default.
• W2024085735 cites W2161759029 @default.
• W2024085735 cites W2272212338 @default.
• W2024085735 cites W2343448033 @default.
• W2024085735 cites W2398218207 @default.
• W2024085735 cites W2398246806 @default.
• W2024085735 cites W2399997114 @default.
• W2024085735 cites W2430895122 @default.
• W2024085735 cites W2463781374 @default.
• W2024085735 doi "https://doi.org/10.1046/j.1460-9568.1998.00358.x" @default.
• W2024085735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9824458" @default.
• W2024085735 hasPublicationYear "1998" @default.
• W2024085735 type Work @default.
• W2024085735 sameAs 2024085735 @default.
• W2024085735 citedByCount "84" @default.
• W2024085735 countsByYear W20240857352012 @default.
• W2024085735 countsByYear W20240857352013 @default.
• W2024085735 countsByYear W20240857352014 @default.
• W2024085735 countsByYear W20240857352015 @default.
• W2024085735 countsByYear W20240857352016 @default.
• W2024085735 countsByYear W20240857352017 @default.
• W2024085735 countsByYear W20240857352018 @default.
• W2024085735 countsByYear W20240857352019 @default.
• W2024085735 countsByYear W20240857352020 @default.
• W2024085735 countsByYear W20240857352021 @default.
• W2024085735 countsByYear W20240857352022 @default.
• W2024085735 countsByYear W20240857352023 @default.
• W2024085735 crossrefType "journal-article" @default.
• W2024085735 hasAuthorship W2024085735A5041699483 @default.
• W2024085735 hasAuthorship W2024085735A5087468075 @default.
• W2024085735 hasConcept C122356138 @default.
• W2024085735 hasConcept C12554922 @default.
• W2024085735 hasConcept C126322002 @default.
• W2024085735 hasConcept C148762608 @default.
• W2024085735 hasConcept C169760540 @default.
• W2024085735 hasConcept C170493617 @default.
• W2024085735 hasConcept C185592680 @default.
• W2024085735 hasConcept C197341189 @default.
• W2024085735 hasConcept C2778541695 @default.
• W2024085735 hasConcept C4141045 @default.
• W2024085735 hasConcept C541997718 @default.
• W2024085735 hasConcept C55493867 @default.
• W2024085735 hasConcept C61174792 @default.
• W2024085735 hasConcept C67018056 @default.
• W2024085735 hasConcept C71924100 @default.
• W2024085735 hasConcept C86803240 @default.
• W2024085735 hasConceptScore W2024085735C122356138 @default.
• W2024085735 hasConceptScore W2024085735C12554922 @default.
• W2024085735 hasConceptScore W2024085735C126322002 @default.
• W2024085735 hasConceptScore W2024085735C148762608 @default.
• W2024085735 hasConceptScore W2024085735C169760540 @default.
• W2024085735 hasConceptScore W2024085735C170493617 @default.
• W2024085735 hasConceptScore W2024085735C185592680 @default.

• next