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- W2024087062 abstract "Intracerebral implants of crystalline testosterone propionate (TP) and dihydrotestosterone propionate (DHTP) were used to determine whether (1) the uncertainty regarding the location of the androgen-sensitive, sexual behavior-activating area of the hypothalamus could be resolved and (2) the failure of DHTP to stimulate sexual behavior in castrates could be overcome by placing the steroid directly at the putative receptor area in the brain. TP implants in the anterior hypothalamic-preoptic area were significantly more effective in restoring copulatory behavior in castrates than were those in the posterior hypothalamus. These results could not be explained by release of testosterone into the systemic circulation. Systemic injections of DHTP were ineffective in maintaining sexual behavior when administered from the day of castration, and DHTP implants in the anterior region were markedly less effective than TP in restoring sexual behavior. Implantation of DHTP in the medial basal hypothalamus, but not the pituitary of immature rats suppressed gonadotropin secretion, as indicated by reduction in growth of testes and sexual accessory glands. It was concluded that (1) androgen-sensitive structures regulating male sexual behavior in the rat are more concentrated in the anterior than the posterior hypothalamic region and (2) testosterone probably does not activate male sexual behavior via conversion to dihydrotestosterone." @default.
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- W2024087062 date "1972-12-01" @default.
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- W2024087062 title "Intracerebral androgens and sexual behavior in the male rat" @default.
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- W2024087062 doi "https://doi.org/10.1016/0018-506x(72)90024-4" @default.
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