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- W2024088369 abstract "In late pregnancy, the hypothalamo-pituitary-adrenal (HPA) axis is less responsive to a range of psychological and physical stressors as a result of reduced central drive to the corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN). Most stressors activate the brain stem noradrenergic system, which innervates the majority of networks involved in regulating stress responses, including the PVN. Forced swimming, systemic interleukin-1beta (IL-1beta), and cholecystokinin (CCK) all activate brain stem noradrenergic cell groups, stimulate noradrenaline release in the PVN, and activate the HPA axis in nonpregnant rats. However, in late pregnancy we have shown that forced swimming and IL-1beta fail to evoke noradrenaline release in the PVN and hence HPA axis responses are suppressed. HPA axis responses to IL-1beta and CCK can be reinstated in pregnant rats by systemic administration of the opioid receptor antagonist naloxone, and when infused directly into the PVN, naloxone restores noradrenaline release in the PVN following IL-1beta treatment. Adrenaline release into the blood following stress is also attenuated in late pregnancy, despite increased adrenomedullary expression of tyrosine hydroxylase mRNA at this time. This review describes the mechanisms underlying attenuated HPA axis stress responses in pregnancy, focusing on the role of endogenous opioids and the central noradrenergic system." @default.
- W2024088369 created "2016-06-24" @default.
- W2024088369 creator A5050530777 @default.
- W2024088369 creator A5060135354 @default.
- W2024088369 creator A5077217228 @default.
- W2024088369 date "2008-12-01" @default.
- W2024088369 modified "2023-09-23" @default.
- W2024088369 title "Reduced Hypothalamo-pituitary-adrenal Axis Stress Responses in Late Pregnancy" @default.
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- W2024088369 doi "https://doi.org/10.1196/annals.1410.032" @default.
- W2024088369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19120138" @default.
- W2024088369 hasPublicationYear "2008" @default.
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