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• W2024088568 abstract "Chronic allograft nephropathy (CAN) is a multifactorial lesion. There has been a gradu-ally increasing recognition of the importance of antigen-independent factors influencingthe development and progression of CAN. One important antigen-independent hor-mone in this setting is angiotensin II (AII), which is associated with progressive kidneydisease. Although the pathogenesis of native kidney disease may differ from CAN, thechronic progressive nature of both entities raises the hypothesis that AII also has a rolein CAN. However, AII also serves as a theoretical focal point, linking many of the factorsinvolved in CAN. Fortunately, we have therapies, angiotensin converting enzyme in-hibitors (ACE-I), and type 1 angiotensin II receptor (AT" @default.
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• W2024088568 date "2002-06-01" @default.
• W2024088568 modified "2023-09-24" @default.
• W2024088568 title "An Antigen-Independent Important Hormone: Intrarenal Angiotensin II (AII) as a Key to Understanding Chronic Allograft Nephropathy" @default.
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• W2024088568 doi "https://doi.org/10.1177/152216280200500402" @default.
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