Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024088725> ?p ?o ?g. }
- W2024088725 endingPage "611" @default.
- W2024088725 startingPage "599" @default.
- W2024088725 abstract "Oestrogen has wide ranging effects in development mediated mainly via the two oestrogen receptors, α (ESR1, also known as ERα) and β (ESR2, also known as ERβ). Oestrogen is the key factor that directs the indifferent gonad to become an ovary in many non-mammalian vertebrates. Oestrogen is not required for early ovarian differentiation in mammals but can disrupt normal testicular development in eutherians. Surprisingly, exogenous oestrogen can cause sex reversal of an XY gonad in two marsupials, the North American opossum and the tammar wallaby. To understand the mechanism by which oestrogen induces sex reversal, we characterised the genes for ESR1 and ESR2 and examined their expression during gonadal differentiation in the tammar wallaby, Macropus eugenii . Both receptors were expressed in the somatic cells and germ cells of the indifferent gonad in both XX and XY foetuses throughout all stages of development, and persisted in these cells into adulthood. ERs were also present in many other tissues including kidney, pituitary and mammary gland. ER mRNA was not significantly altered by exogenous oestrogen in cultured XY gonads but the receptors translocated to the nucleus in its presence. These findings confirm that there is conserved expression of the ERs in the indifferent gonad despite the lack of available ligand during early gonadal development. The receptors can respond to exogenous estrogen at this early stage and are capable of transducing signals in the early mammalian gonad. However, the selective forces that maintained conserved ER expression in this tissue remain unknown." @default.
- W2024088725 created "2016-06-24" @default.
- W2024088725 creator A5021054750 @default.
- W2024088725 creator A5024210617 @default.
- W2024088725 creator A5027940556 @default.
- W2024088725 creator A5039973322 @default.
- W2024088725 creator A5059662490 @default.
- W2024088725 creator A5078541466 @default.
- W2024088725 date "2010-03-01" @default.
- W2024088725 modified "2023-10-18" @default.
- W2024088725 title "Ontogeny of the oestrogen receptors ESR1 and ESR2 during gonadal development in the tammar wallaby, Macropus eugenii" @default.
- W2024088725 cites W1211342233 @default.
- W2024088725 cites W1541234884 @default.
- W2024088725 cites W1547137876 @default.
- W2024088725 cites W1963785171 @default.
- W2024088725 cites W1964737314 @default.
- W2024088725 cites W1965850432 @default.
- W2024088725 cites W1966684450 @default.
- W2024088725 cites W1971365457 @default.
- W2024088725 cites W1973723475 @default.
- W2024088725 cites W1973732113 @default.
- W2024088725 cites W1979238526 @default.
- W2024088725 cites W1979495648 @default.
- W2024088725 cites W1980379549 @default.
- W2024088725 cites W1980996548 @default.
- W2024088725 cites W1983413807 @default.
- W2024088725 cites W1987522025 @default.
- W2024088725 cites W1988719974 @default.
- W2024088725 cites W1997412994 @default.
- W2024088725 cites W2001286676 @default.
- W2024088725 cites W2006624743 @default.
- W2024088725 cites W2007210732 @default.
- W2024088725 cites W2008071275 @default.
- W2024088725 cites W2010385372 @default.
- W2024088725 cites W2012425172 @default.
- W2024088725 cites W2013594510 @default.
- W2024088725 cites W2020121310 @default.
- W2024088725 cites W2026207114 @default.
- W2024088725 cites W2027208794 @default.
- W2024088725 cites W2036507321 @default.
- W2024088725 cites W2036853383 @default.
- W2024088725 cites W2040832608 @default.
- W2024088725 cites W2045256755 @default.
- W2024088725 cites W2048159918 @default.
- W2024088725 cites W2048561091 @default.
- W2024088725 cites W2049963065 @default.
- W2024088725 cites W2051456403 @default.
- W2024088725 cites W2060773377 @default.
- W2024088725 cites W2067233094 @default.
- W2024088725 cites W2069732337 @default.
- W2024088725 cites W2071843885 @default.
- W2024088725 cites W2075788654 @default.
- W2024088725 cites W2076127338 @default.
- W2024088725 cites W2080036473 @default.
- W2024088725 cites W2080543032 @default.
- W2024088725 cites W2083759568 @default.
- W2024088725 cites W2095724872 @default.
- W2024088725 cites W2100534001 @default.
- W2024088725 cites W2100837269 @default.
- W2024088725 cites W2102038031 @default.
- W2024088725 cites W2108059256 @default.
- W2024088725 cites W2108244474 @default.
- W2024088725 cites W2111546937 @default.
- W2024088725 cites W2113803259 @default.
- W2024088725 cites W2115263123 @default.
- W2024088725 cites W2120653485 @default.
- W2024088725 cites W2124647435 @default.
- W2024088725 cites W2128242453 @default.
- W2024088725 cites W2141269411 @default.
- W2024088725 cites W2144613977 @default.
- W2024088725 cites W2148769188 @default.
- W2024088725 cites W2148788638 @default.
- W2024088725 cites W2153596741 @default.
- W2024088725 cites W2153788144 @default.
- W2024088725 cites W2154937055 @default.
- W2024088725 cites W2161623422 @default.
- W2024088725 cites W2164460703 @default.
- W2024088725 cites W2165265831 @default.
- W2024088725 cites W2169906319 @default.
- W2024088725 cites W2170413583 @default.
- W2024088725 cites W2170728568 @default.
- W2024088725 cites W2407987762 @default.
- W2024088725 cites W4230586707 @default.
- W2024088725 cites W4237395980 @default.
- W2024088725 cites W4240813486 @default.
- W2024088725 cites W4240866307 @default.
- W2024088725 cites W4241798958 @default.
- W2024088725 cites W4243058136 @default.
- W2024088725 cites W4244458422 @default.
- W2024088725 cites W4245298796 @default.
- W2024088725 cites W4245927460 @default.
- W2024088725 cites W4245935781 @default.
- W2024088725 cites W4248453414 @default.
- W2024088725 cites W4249012312 @default.
- W2024088725 cites W4251593031 @default.
- W2024088725 cites W4254205284 @default.
- W2024088725 doi "https://doi.org/10.1530/rep-09-0305" @default.
- W2024088725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20028801" @default.