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• W2024089744 endingPage "3140" @default.
• W2024089744 startingPage "3131" @default.
• W2024089744 abstract "The purpose of the present study was to determine the relative amount of S-thiolated proteins (i.e. S-homocysteinylated, S-cysteinylglycinylated, S-glutathionylated and S-cysteinylated proteins) to the total protein thiols (i.e. the sum of reduced protein sulphydryl groups (PSHs) and protein mixed disulphides with homocysteine [HcySH], cysteinylglycine, cysteine [CysSH] and glutathione) in the plasma of healthy individuals aged 20 to 93. After plasma separation, total protein thiols, S-thiolated proteins, as well as CysSH, cystine, HcySH and homocystine were measured by high-performance liquid chromatography (HPLC) with fluorescence determination of the thiol-monobromobimane conjugate. Determination of plasma levels of protein thiols was performed by spectrophotometry with 5,5'-dithiobis(2-nitrobenzoic acid) as a titrating agent. The present study demonstrates an age-dependent reduction in the amount of PSHs, and an age-dependent increase in cysteinylated and homocysteinylated plasma proteins in healthy human beings. This indicates that the efficiency of the reduced protein thiol pool as an antioxidant defence system decreases with age, possibly causing an increased risk of irreversible oxidation (i.e. further oxidation to sulphinic and sulphonic acids, which are usually not reducible by thiol reducing agents) of sulphydryl groups of plasma proteins. The drop in the plasma level of protein sulphydryl groups suggests depletion and/or impairment of the antioxidant capacity of plasma, likely related to an alteration of the delicate balance between the different redox forms of thiols." @default.
• W2024089744 created "2016-06-24" @default.
• W2024089744 creator A5018604525 @default.
• W2024089744 creator A5021943550 @default.
• W2024089744 creator A5069021426 @default.
• W2024089744 creator A5078717520 @default.
• W2024089744 date "2009-09-01" @default.
• W2024089744 modified "2023-10-11" @default.
• W2024089744 title "Cysteinylation and homocysteinylation of plasma protein thiols during ageing of healthy human beings" @default.
• W2024089744 cites W1964160853 @default.
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• W2024089744 cites W1971983381 @default.
• W2024089744 cites W1972054336 @default.
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• W2024089744 cites W1983588291 @default.
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• W2024089744 doi "https://doi.org/10.1111/j.1582-4934.2008.00417.x" @default.
• W2024089744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4516472" @default.
• W2024089744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18624771" @default.
• W2024089744 hasPublicationYear "2009" @default.
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