Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024091609> ?p ?o ?g. }
- W2024091609 endingPage "102" @default.
- W2024091609 startingPage "98" @default.
- W2024091609 abstract "Tea is widely consumed all over the world. Studies have demonstrated the role of tea in prevention and treatment of various chronic diseases including diabetes and obesity, but the underlying mechanism is unclear. PTP1B is a widely expressed tyrosine phosphatase which has been defined as a target for therapeutic drug development to treat diabetes and obesity. In screening for inhibitors of PTP1B, we found that aqueous extracts of teas exhibited potent PTP1B inhibitory effects with an IC50 value of 0.4–4 g dry tea leaves per liter of water. Black tea shows the strongest inhibition activities, followed by oolong and then by green tea. Biochemical fractionations demonstrated that the major effective components in tea corresponded to oxidized polyphenolic compounds. This was further verified by the fact that tea catechins became potent inhibitors of PTP1B upon oxidation catalyzed by tyrosinases. When applied to cultured cells, tea extracts induced tyrosine phosphorylation of cellular proteins. Our study suggests that some beneficial effects of tea may be attributed to the inhibition of PTP1B." @default.
- W2024091609 created "2016-06-24" @default.
- W2024091609 creator A5023826377 @default.
- W2024091609 creator A5036460042 @default.
- W2024091609 creator A5052066751 @default.
- W2024091609 creator A5052717498 @default.
- W2024091609 creator A5062050451 @default.
- W2024091609 creator A5063208606 @default.
- W2024091609 date "2011-04-01" @default.
- W2024091609 modified "2023-10-17" @default.
- W2024091609 title "Tea contains potent inhibitors of tyrosine phosphatase PTP1B" @default.
- W2024091609 cites W1483136397 @default.
- W2024091609 cites W1496740734 @default.
- W2024091609 cites W1497274503 @default.
- W2024091609 cites W1565831796 @default.
- W2024091609 cites W1969918683 @default.
- W2024091609 cites W1970736635 @default.
- W2024091609 cites W1988456343 @default.
- W2024091609 cites W1992960967 @default.
- W2024091609 cites W2000519650 @default.
- W2024091609 cites W2001190301 @default.
- W2024091609 cites W2005955483 @default.
- W2024091609 cites W2013948951 @default.
- W2024091609 cites W2024727248 @default.
- W2024091609 cites W2028754675 @default.
- W2024091609 cites W2032440198 @default.
- W2024091609 cites W2036164471 @default.
- W2024091609 cites W2038314648 @default.
- W2024091609 cites W2043617798 @default.
- W2024091609 cites W2044939926 @default.
- W2024091609 cites W2054575721 @default.
- W2024091609 cites W2071006062 @default.
- W2024091609 cites W2078651468 @default.
- W2024091609 cites W2083749076 @default.
- W2024091609 cites W2086170696 @default.
- W2024091609 cites W2087482176 @default.
- W2024091609 cites W2090727292 @default.
- W2024091609 cites W2091988898 @default.
- W2024091609 cites W2098854471 @default.
- W2024091609 cites W2112532934 @default.
- W2024091609 cites W2114057457 @default.
- W2024091609 cites W2115681043 @default.
- W2024091609 cites W2123229219 @default.
- W2024091609 cites W2129305960 @default.
- W2024091609 cites W2134179323 @default.
- W2024091609 cites W2150392518 @default.
- W2024091609 cites W2150630317 @default.
- W2024091609 cites W2154256245 @default.
- W2024091609 cites W2158902159 @default.
- W2024091609 cites W2166856678 @default.
- W2024091609 cites W4241472476 @default.
- W2024091609 doi "https://doi.org/10.1016/j.bbrc.2011.02.116" @default.
- W2024091609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3070786" @default.
- W2024091609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21371422" @default.
- W2024091609 hasPublicationYear "2011" @default.
- W2024091609 type Work @default.
- W2024091609 sameAs 2024091609 @default.
- W2024091609 citedByCount "18" @default.
- W2024091609 countsByYear W20240916092012 @default.
- W2024091609 countsByYear W20240916092013 @default.
- W2024091609 countsByYear W20240916092015 @default.
- W2024091609 countsByYear W20240916092016 @default.
- W2024091609 countsByYear W20240916092017 @default.
- W2024091609 countsByYear W20240916092018 @default.
- W2024091609 countsByYear W20240916092019 @default.
- W2024091609 countsByYear W20240916092020 @default.
- W2024091609 countsByYear W20240916092021 @default.
- W2024091609 countsByYear W20240916092022 @default.
- W2024091609 countsByYear W20240916092023 @default.
- W2024091609 crossrefType "journal-article" @default.
- W2024091609 hasAuthorship W2024091609A5023826377 @default.
- W2024091609 hasAuthorship W2024091609A5036460042 @default.
- W2024091609 hasAuthorship W2024091609A5052066751 @default.
- W2024091609 hasAuthorship W2024091609A5052717498 @default.
- W2024091609 hasAuthorship W2024091609A5062050451 @default.
- W2024091609 hasAuthorship W2024091609A5063208606 @default.
- W2024091609 hasBestOaLocation W20240916092 @default.
- W2024091609 hasConcept C178666793 @default.
- W2024091609 hasConcept C181199279 @default.
- W2024091609 hasConcept C185592680 @default.
- W2024091609 hasConcept C202751555 @default.
- W2024091609 hasConcept C2776165026 @default.
- W2024091609 hasConcept C2777752497 @default.
- W2024091609 hasConcept C2778004101 @default.
- W2024091609 hasConcept C2779431889 @default.
- W2024091609 hasConcept C2992231244 @default.
- W2024091609 hasConcept C2992814287 @default.
- W2024091609 hasConcept C2992816389 @default.
- W2024091609 hasConcept C31903555 @default.
- W2024091609 hasConcept C55493867 @default.
- W2024091609 hasConcept C59822182 @default.
- W2024091609 hasConcept C70899900 @default.
- W2024091609 hasConcept C85528070 @default.
- W2024091609 hasConcept C86803240 @default.
- W2024091609 hasConcept C98274493 @default.
- W2024091609 hasConceptScore W2024091609C178666793 @default.
- W2024091609 hasConceptScore W2024091609C181199279 @default.
- W2024091609 hasConceptScore W2024091609C185592680 @default.