Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024093325> ?p ?o ?g. }
- W2024093325 endingPage "281" @default.
- W2024093325 startingPage "271" @default.
- W2024093325 abstract "Transient receptor potential melastatin 2 (TRPM2) highly expressed in immunocytes is a Ca(2+)-permeable non-selective cation channel activated by oxidative stress. Myocardial ischaemia/reperfusion (I/R) injury is characterized by acute inflammation associated with the augmentation of oxidative stress. We hypothesized that TRPM2 is implicated in the exacerbation of myocardial I/R injury.Wild-type (Trpm2(+/+)) and Trpm2 knockout (Trpm2(-/-)) mice were subjected to ligation of the left main coronary artery followed by reperfusion. Myocardial infarction following I/R, but not ischaemia alone, was reduced more in Trpm2(-/-)mice than in Trpm2(+/+) mice and cardiac contractile functions were also improved in Trpm2(-/-)mice. TRPM2 was highly expressed in the polymorphonuclear leucocytes (PMNs) rather than in the heart. The number of neutrophils and myeloperoxidase (MPO) activity in the reperfused area following ischaemia was lowered in Trpm2(-/-) mice. When Trpm2(+)(/+) or Trpm2(-/-) PMNs were administered to the Trpm2(-/-) heart ex vivo through the perfusate or in vivo by iv injection, Trpm2(+)(/+) PMNs produced enlargement of the infarct size. Following in vitro regional I/R, a pharmacological inhibitor of TRPM2 reduced the infarct size. The combination of H(2)O(2) and leukotriene B(4) (LTB(4)) increased intracellular Ca(2+) concentration and their adhesion to endothelial cells in Trpm2(+)(/+) but not in Trpm2(-/-)PMNs.These findings indicate that neutrophil TRPM2 is implicated in the exacerbation of myocardial reperfusion injury. Accumulation of neutrophils in the reperfused area mediated by TRPM2 activation is likely to play a crucial role in myocardial I/R injury." @default.
- W2024093325 created "2016-06-24" @default.
- W2024093325 creator A5022886115 @default.
- W2024093325 creator A5031234732 @default.
- W2024093325 creator A5034568368 @default.
- W2024093325 creator A5044478801 @default.
- W2024093325 creator A5052465822 @default.
- W2024093325 creator A5075184369 @default.
- W2024093325 creator A5078365630 @default.
- W2024093325 creator A5078967543 @default.
- W2024093325 date "2012-11-05" @default.
- W2024093325 modified "2023-10-05" @default.
- W2024093325 title "Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury" @default.
- W2024093325 cites W1518705238 @default.
- W2024093325 cites W1537218374 @default.
- W2024093325 cites W1542697059 @default.
- W2024093325 cites W1963748663 @default.
- W2024093325 cites W1964462170 @default.
- W2024093325 cites W1974955556 @default.
- W2024093325 cites W1983434116 @default.
- W2024093325 cites W1992484312 @default.
- W2024093325 cites W2006471221 @default.
- W2024093325 cites W2007252146 @default.
- W2024093325 cites W2007525497 @default.
- W2024093325 cites W2011513090 @default.
- W2024093325 cites W2014280822 @default.
- W2024093325 cites W2017035419 @default.
- W2024093325 cites W2028316401 @default.
- W2024093325 cites W2029699231 @default.
- W2024093325 cites W2035808762 @default.
- W2024093325 cites W2040200395 @default.
- W2024093325 cites W2049324676 @default.
- W2024093325 cites W2050744280 @default.
- W2024093325 cites W2060701666 @default.
- W2024093325 cites W2066346206 @default.
- W2024093325 cites W2067775666 @default.
- W2024093325 cites W2076442408 @default.
- W2024093325 cites W2078745766 @default.
- W2024093325 cites W2080290131 @default.
- W2024093325 cites W2098058049 @default.
- W2024093325 cites W2110366350 @default.
- W2024093325 cites W2110827218 @default.
- W2024093325 cites W2118270110 @default.
- W2024093325 cites W2132486552 @default.
- W2024093325 cites W2138621771 @default.
- W2024093325 cites W2148994398 @default.
- W2024093325 cites W2151388489 @default.
- W2024093325 cites W2155135898 @default.
- W2024093325 cites W2158847036 @default.
- W2024093325 cites W2160442213 @default.
- W2024093325 cites W2167318614 @default.
- W2024093325 cites W2168838919 @default.
- W2024093325 doi "https://doi.org/10.1093/cvr/cvs332" @default.
- W2024093325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23129587" @default.
- W2024093325 hasPublicationYear "2012" @default.
- W2024093325 type Work @default.
- W2024093325 sameAs 2024093325 @default.
- W2024093325 citedByCount "94" @default.
- W2024093325 countsByYear W20240933252012 @default.
- W2024093325 countsByYear W20240933252013 @default.
- W2024093325 countsByYear W20240933252014 @default.
- W2024093325 countsByYear W20240933252015 @default.
- W2024093325 countsByYear W20240933252016 @default.
- W2024093325 countsByYear W20240933252017 @default.
- W2024093325 countsByYear W20240933252018 @default.
- W2024093325 countsByYear W20240933252019 @default.
- W2024093325 countsByYear W20240933252020 @default.
- W2024093325 countsByYear W20240933252021 @default.
- W2024093325 countsByYear W20240933252022 @default.
- W2024093325 countsByYear W20240933252023 @default.
- W2024093325 crossrefType "journal-article" @default.
- W2024093325 hasAuthorship W2024093325A5022886115 @default.
- W2024093325 hasAuthorship W2024093325A5031234732 @default.
- W2024093325 hasAuthorship W2024093325A5034568368 @default.
- W2024093325 hasAuthorship W2024093325A5044478801 @default.
- W2024093325 hasAuthorship W2024093325A5052465822 @default.
- W2024093325 hasAuthorship W2024093325A5075184369 @default.
- W2024093325 hasAuthorship W2024093325A5078365630 @default.
- W2024093325 hasAuthorship W2024093325A5078967543 @default.
- W2024093325 hasConcept C126322002 @default.
- W2024093325 hasConcept C151495721 @default.
- W2024093325 hasConcept C155164980 @default.
- W2024093325 hasConcept C170493617 @default.
- W2024093325 hasConcept C185592680 @default.
- W2024093325 hasConcept C202751555 @default.
- W2024093325 hasConcept C26291073 @default.
- W2024093325 hasConcept C2776151105 @default.
- W2024093325 hasConcept C2776914184 @default.
- W2024093325 hasConcept C541997718 @default.
- W2024093325 hasConcept C55493867 @default.
- W2024093325 hasConcept C71924100 @default.
- W2024093325 hasConcept C98274493 @default.
- W2024093325 hasConceptScore W2024093325C126322002 @default.
- W2024093325 hasConceptScore W2024093325C151495721 @default.
- W2024093325 hasConceptScore W2024093325C155164980 @default.
- W2024093325 hasConceptScore W2024093325C170493617 @default.
- W2024093325 hasConceptScore W2024093325C185592680 @default.
- W2024093325 hasConceptScore W2024093325C202751555 @default.