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• W2024095951 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Mar 2002URINARY CONCENTRATION AND TISSUE MESSENGER RNA EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 AS AN INDICATOR OF THE DEGREE OF HYDRONEPHROTIC ATROPHY IN PARTIAL URETERAL OBSTRUCTION MIRIAM STEPHAN, STEFAN CONRAD, THILO EGGERT, ROMAN HEUER, SALVADOR FERNANDEZ, and HARTWIG HULAND MIRIAM STEPHANMIRIAM STEPHAN More articles by this author , STEFAN CONRADSTEFAN CONRAD More articles by this author , THILO EGGERTTHILO EGGERT More articles by this author , ROMAN HEUERROMAN HEUER More articles by this author , SALVADOR FERNANDEZSALVADOR FERNANDEZ More articles by this author , and HARTWIG HULANDHARTWIG HULAND More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65352-9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: To find a potential prognostic marker of the induction of hydronephrotic atrophy in congenital hydronephrosis we investigated whether the messenger (m)RNA expression and urinary concentration of monocyte chemoattractant protein-1 (MCP-1) correlated with the degree of partial ureteral obstruction, and subsequent hydronephrotic atrophy and interstitial fibrosis. Materials and Methods: We created left partial ureteral obstruction in 96 juvenile Wistar rats and complete ureteral obstruction in 18, while 16 underwent sham operation. Depending on excretion of contrast medium into the renal pelvis after 3 days we defined 2 degrees of hydronephrosis. Renal mRNA expression of MCP-1, and renal pelvic and bladder urinary concentrations of MCP-1 were measured after 1, 2 and 3 weeks, and compared with the degree of hydronephrotic atrophy. Results: Grade 1 partial ureteral obstruction resulted in mild histological changes. Grade 2 partial and complete obstruction resulted in significant hydronephrotic atrophy. MCP-1 mRNA expression in the kidney remained unchanged in grade 1 partial obstruction but was moderately increased in grade 2 partial obstruction and clearly over expressed in complete ureteral obstruction. The renal pelvic urinary concentration of MCP-1 was not higher in rats with grade 1 partial obstruction than in sham operated animals but it was significantly increased in those with grade 2 partial and complete obstruction. Conclusions: mRNA expression and the urinary concentration of MCP-1 correlate with the degree of obstruction and subsequent renal damage in hydronephrosis. They may serve as prognostic markers in children with congenital hydronephrosis. References 1 : The postnatal management of hydronephrosis diagnosed by prenatal ultrasound. J Urol1990; 144: 584. Link, Google Scholar 2 : The non-operative management of unilateral neonatal hydronephrosis: natural history of poorly functioning kidneys.. J Urol1994; 152: 593. Abstract, Google Scholar 3 : Prenatally diagnosed hydronephrosis: the Great Ormond Street experience. Br J Urol, suppl.1998; 81: 39. Google Scholar 4 : Changing concepts in management of primary obstructive megaureter. J Urol1989; 142: 636. 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Google Scholar From the Department of Urology, University of Hamburg, Eppendorf University Hospital, Hamburg, Germany© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byCHEVALIER R (2018) BIOMARKERS OF CONGENITAL OBSTRUCTIVE NEPHROPATHY: PAST, PRESENT AND FUTUREJournal of Urology, VOL. 172, NO. 3, (852-857), Online publication date: 1-Sep-2004. Volume 167Issue 3March 2002Page: 1497-1502 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordsrats, Wistarhydronephrosisureteral obstructionkidneymonocyte chemoattractant protein-1MetricsAuthor Information MIRIAM STEPHAN More articles by this author STEFAN CONRAD More articles by this author THILO EGGERT More articles by this author ROMAN HEUER More articles by this author SALVADOR FERNANDEZ More articles by this author HARTWIG HULAND More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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