Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024098081> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2024098081 abstract "Alzheimer's disease (AD) is characterized by several pathological lesions, in particular senile plaques (SPs), cerebral amyloid angiopathy (CAA) and neurofibrillary tangles (NFTs), predominantly consisting of self-aggregated proteins amyloid-beta (Aβ) and tau, respectively. Transglutaminases (TGases) are inducible enzymes, capable of modifying the conformational and/or structural properties of proteins, such as Aβ and tau, by inducing intra- and intermolecular covalent cross-links. Both Aβ and tau are substrates for TGase cross-linking activity, which suggests that TGases play a role in the initiation and persistence of the aggregation process of both Aβ and tau in AD brains. The aim of this study was to investigate the association of Transglutaminase 1 (TG1), Transglutaminase 2 (TG2) and TG-catalyzed cross-links with the pathological lesions of AD. For this purpose, a panel of well-characterized antibodies against TG1, TG2 and the TG-catalyzed cross-links was used in immunohistochemistry. We observed the immunoreactivity for TG1, TG2 and TG-catalyzed cross-links in NFTs. In addition, both TG2 and TG-catalyzed cross-links colocalize with Aβ in SPs. Furthermore, staining of TG2 and TG-catalyzed antibodies was also observed in CAA, although specific colocalization with deposited Aβ in CAA was absent. We conclude that both TG1 and TG2 are present in SPs, CAA and NFTs, and that these enzymes display cross-linking activity in AD lesions. We suggest that both TG1 and TG2 are involved in the initiation and/or persistence of the protein aggregation processes underlying the formation of SPs and CAA, and NFTs in AD brain." @default.
- W2024098081 created "2016-06-24" @default.
- W2024098081 creator A5000135568 @default.
- W2024098081 creator A5014287588 @default.
- W2024098081 creator A5065120938 @default.
- W2024098081 creator A5078899624 @default.
- W2024098081 creator A5084308010 @default.
- W2024098081 creator A5089717369 @default.
- W2024098081 date "2008-07-01" @default.
- W2024098081 modified "2023-09-27" @default.
- W2024098081 title "P4-160: Transglutaminase 1, Transglutaminase 2 and Transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain" @default.
- W2024098081 doi "https://doi.org/10.1016/j.jalz.2008.05.2227" @default.
- W2024098081 hasPublicationYear "2008" @default.
- W2024098081 type Work @default.
- W2024098081 sameAs 2024098081 @default.
- W2024098081 citedByCount "0" @default.
- W2024098081 crossrefType "journal-article" @default.
- W2024098081 hasAuthorship W2024098081A5000135568 @default.
- W2024098081 hasAuthorship W2024098081A5014287588 @default.
- W2024098081 hasAuthorship W2024098081A5065120938 @default.
- W2024098081 hasAuthorship W2024098081A5078899624 @default.
- W2024098081 hasAuthorship W2024098081A5084308010 @default.
- W2024098081 hasAuthorship W2024098081A5089717369 @default.
- W2024098081 hasBestOaLocation W20240980811 @default.
- W2024098081 hasConcept C136238340 @default.
- W2024098081 hasConcept C142724271 @default.
- W2024098081 hasConcept C153911025 @default.
- W2024098081 hasConcept C178498320 @default.
- W2024098081 hasConcept C181199279 @default.
- W2024098081 hasConcept C185592680 @default.
- W2024098081 hasConcept C204232928 @default.
- W2024098081 hasConcept C2777790613 @default.
- W2024098081 hasConcept C2779134260 @default.
- W2024098081 hasConcept C2779483572 @default.
- W2024098081 hasConcept C40209533 @default.
- W2024098081 hasConcept C502032728 @default.
- W2024098081 hasConcept C55493867 @default.
- W2024098081 hasConcept C68026918 @default.
- W2024098081 hasConcept C71924100 @default.
- W2024098081 hasConcept C86803240 @default.
- W2024098081 hasConcept C95444343 @default.
- W2024098081 hasConceptScore W2024098081C136238340 @default.
- W2024098081 hasConceptScore W2024098081C142724271 @default.
- W2024098081 hasConceptScore W2024098081C153911025 @default.
- W2024098081 hasConceptScore W2024098081C178498320 @default.
- W2024098081 hasConceptScore W2024098081C181199279 @default.
- W2024098081 hasConceptScore W2024098081C185592680 @default.
- W2024098081 hasConceptScore W2024098081C204232928 @default.
- W2024098081 hasConceptScore W2024098081C2777790613 @default.
- W2024098081 hasConceptScore W2024098081C2779134260 @default.
- W2024098081 hasConceptScore W2024098081C2779483572 @default.
- W2024098081 hasConceptScore W2024098081C40209533 @default.
- W2024098081 hasConceptScore W2024098081C502032728 @default.
- W2024098081 hasConceptScore W2024098081C55493867 @default.
- W2024098081 hasConceptScore W2024098081C68026918 @default.
- W2024098081 hasConceptScore W2024098081C71924100 @default.
- W2024098081 hasConceptScore W2024098081C86803240 @default.
- W2024098081 hasConceptScore W2024098081C95444343 @default.
- W2024098081 hasIssue "4S_Part_22" @default.
- W2024098081 hasLocation W20240980811 @default.
- W2024098081 hasOpenAccess W2024098081 @default.
- W2024098081 hasPrimaryLocation W20240980811 @default.
- W2024098081 hasRelatedWork W1993598577 @default.
- W2024098081 hasRelatedWork W2007586650 @default.
- W2024098081 hasRelatedWork W2024098081 @default.
- W2024098081 hasRelatedWork W2028502857 @default.
- W2024098081 hasRelatedWork W2046725122 @default.
- W2024098081 hasRelatedWork W2099495321 @default.
- W2024098081 hasRelatedWork W2111898865 @default.
- W2024098081 hasRelatedWork W2192827948 @default.
- W2024098081 hasRelatedWork W2412839611 @default.
- W2024098081 hasRelatedWork W4230537717 @default.
- W2024098081 hasVolume "4" @default.
- W2024098081 isParatext "false" @default.
- W2024098081 isRetracted "false" @default.
- W2024098081 magId "2024098081" @default.
- W2024098081 workType "article" @default.