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- W2024100316 abstract "Cryopreservation of human blood vessels may become an important tool in bypass surgery and peripheral vascular reconstruction. Ideally cryopreservation of a blood vessel should preserve functional characteristics comparable to those of fresh controls. The key advantage of cryopreservation is the fact that storage at deep subzero temperatures allows storage of structurally intact living vascular tissues for virtually infinite time. Originally developed for long-time storage of isolated cells, the techniques of cryopreservation of tissues are challenged by the fact that these are complex multicellular systems containing diverse types of cells with differing requirements for optimal preservation. Therefore, the post-thaw functional activity of vascular tissues is determined by the type of blood vessel and, in addition, by the cell packing effect. Moreover, evidence from pharmacological studies suggests that cryopreservation induces tissue specific changes in transmembrane signaling and the mechanisms coupling intracellular calcium release, sensitivity and calcium entry into the smooth muscle cells." @default.
- W2024100316 created "2016-06-24" @default.
- W2024100316 creator A5089579871 @default.
- W2024100316 date "2009-07-01" @default.
- W2024100316 modified "2023-09-27" @default.
- W2024100316 title "Cryopreservation of vascular tissues" @default.
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- W2024100316 doi "https://doi.org/10.4161/org.5.3.9495" @default.
- W2024100316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2781088" @default.
- W2024100316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20046671" @default.
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