FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024100984> ?p ?o ?g. }

• W2024100984 endingPage "8224" @default.
• W2024100984 startingPage "8214" @default.
• W2024100984 abstract "The severe acute respiratory syndrome coronavirus (SARS-CoV) envelope spike (S) glycoprotein, a class I viral fusion protein, is responsible for the fusion between the membranes of the virus and the target cell. The S2 domain of protein S has been suggested to have two fusion peptides, one located at its N-terminus, downstream of the furin cleavage, and another, more internal, located immediately upstream of the HR1. Therefore, we have carried out a study of the binding and interaction with model membranes of a peptide corresponding to segment 873−888 of the SARS-CoV S glycoprotein, peptide SARSIFP, as well as the structural changes taking place in both the phospholipid and the peptide induced by the binding of the peptide to the membrane. We demonstrate that SARSIFP peptide binds to and interacts with phospholipid model membranes and shows a higher affinity for negatively charged phospholipids than for zwitterionic ones. SARSIFP peptide specifically decreases the mobility of the phospholipid acyl chains of negatively charged phospholipids and adopts different conformations in the membrane depending upon their composition. These data support its role in SARS-mediated membrane fusion and suggest that the regions where this peptide resides might assist the fusion peptide and/or the pretransmembrane segment of the SARS-CoV spike glycoprotein in the fusion process." @default.
• W2024100984 created "2016-06-24" @default.
• W2024100984 creator A5037342930 @default.
• W2024100984 creator A5047948559 @default.
• W2024100984 creator A5053847144 @default.
• W2024100984 creator A5054470710 @default.
• W2024100984 date "2008-07-11" @default.
• W2024100984 modified "2023-10-14" @default.
• W2024100984 title "A Second SARS-CoV S2 Glycoprotein Internal Membrane-Active Peptide. Biophysical Characterization and Membrane Interaction" @default.
• W2024100984 cites W1617965928 @default.
• W2024100984 cites W1966238900 @default.
• W2024100984 cites W1970609848 @default.
• W2024100984 cites W1973022948 @default.
• W2024100984 cites W1981969349 @default.
• W2024100984 cites W1983353235 @default.
• W2024100984 cites W1986516374 @default.
• W2024100984 cites W1989270637 @default.
• W2024100984 cites W1990985479 @default.
• W2024100984 cites W1995086122 @default.
• W2024100984 cites W1995660753 @default.
• W2024100984 cites W1996679057 @default.
• W2024100984 cites W2004988715 @default.
• W2024100984 cites W2012521659 @default.
• W2024100984 cites W2012835230 @default.
• W2024100984 cites W2016445477 @default.
• W2024100984 cites W2017814330 @default.
• W2024100984 cites W2020457591 @default.
• W2024100984 cites W2026445898 @default.
• W2024100984 cites W2029681021 @default.
• W2024100984 cites W2031014666 @default.
• W2024100984 cites W2036815287 @default.
• W2024100984 cites W2038604269 @default.
• W2024100984 cites W2039663472 @default.
• W2024100984 cites W2042564924 @default.
• W2024100984 cites W2053417167 @default.
• W2024100984 cites W2060703503 @default.
• W2024100984 cites W2067214744 @default.
• W2024100984 cites W2067531222 @default.
• W2024100984 cites W2068419533 @default.
• W2024100984 cites W2071371875 @default.
• W2024100984 cites W2071857481 @default.
• W2024100984 cites W2079299886 @default.
• W2024100984 cites W2085183163 @default.
• W2024100984 cites W2091001172 @default.
• W2024100984 cites W2092568903 @default.
• W2024100984 cites W2092571716 @default.
• W2024100984 cites W2093110887 @default.
• W2024100984 cites W2096145431 @default.
• W2024100984 cites W2097188280 @default.
• W2024100984 cites W2102264945 @default.
• W2024100984 cites W2106967530 @default.
• W2024100984 cites W2110820282 @default.
• W2024100984 cites W2111005311 @default.
• W2024100984 cites W2114551787 @default.
• W2024100984 cites W2116586125 @default.
• W2024100984 cites W2119047614 @default.
• W2024100984 cites W2119586900 @default.
• W2024100984 cites W2124198028 @default.
• W2024100984 cites W2126036997 @default.
• W2024100984 cites W2128002736 @default.
• W2024100984 cites W2129854963 @default.
• W2024100984 cites W2129995310 @default.
• W2024100984 cites W2135934596 @default.
• W2024100984 cites W2138237585 @default.
• W2024100984 cites W2145607970 @default.
• W2024100984 cites W2170933940 @default.
• W2024100984 doi "https://doi.org/10.1021/bi800814q" @default.
• W2024100984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18616295" @default.
• W2024100984 hasPublicationYear "2008" @default.
• W2024100984 type Work @default.
• W2024100984 sameAs 2024100984 @default.
• W2024100984 citedByCount "37" @default.
• W2024100984 countsByYear W20241009842012 @default.
• W2024100984 countsByYear W20241009842013 @default.
• W2024100984 countsByYear W20241009842014 @default.
• W2024100984 countsByYear W20241009842015 @default.
• W2024100984 countsByYear W20241009842016 @default.
• W2024100984 countsByYear W20241009842018 @default.
• W2024100984 countsByYear W20241009842019 @default.
• W2024100984 countsByYear W20241009842020 @default.
• W2024100984 countsByYear W20241009842021 @default.
• W2024100984 countsByYear W20241009842022 @default.
• W2024100984 countsByYear W20241009842023 @default.
• W2024100984 crossrefType "journal-article" @default.
• W2024100984 hasAuthorship W2024100984A5037342930 @default.
• W2024100984 hasAuthorship W2024100984A5047948559 @default.
• W2024100984 hasAuthorship W2024100984A5053847144 @default.
• W2024100984 hasAuthorship W2024100984A5054470710 @default.
• W2024100984 hasConcept C103038307 @default.
• W2024100984 hasConcept C108625454 @default.
• W2024100984 hasConcept C12554922 @default.
• W2024100984 hasConcept C181199279 @default.
• W2024100984 hasConcept C185592680 @default.
• W2024100984 hasConcept C2777265534 @default.
• W2024100984 hasConcept C2778918659 @default.
• W2024100984 hasConcept C2779281246 @default.
• W2024100984 hasConcept C41625074 @default.
• W2024100984 hasConcept C55493867 @default.

• next