Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024101024> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2024101024 endingPage "57" @default.
- W2024101024 startingPage "53" @default.
- W2024101024 abstract "About 12,000 Americans are diagnosed with malignant astrocytoma each year. Despite surgery, radiotherapy, and chemotherapy, the prognosis of these patients remains poor. Targeted toxins based on the identification of novel antigens or receptors provide a promising new approach to treating cancer. We have identified one such cell surface protein in the form of interleukin (IL)-4 receptors (IL-4R) on human malignant astrocytoma. Normal brain tissues from frontal cortex and temporal lobe cortex do not express IL-4R. To target IL-4R, we generated a chimeric fusion protein composed of IL-4 and Pseudomonas exotoxin (IL4-PE). This toxin is highly cytotoxic to IL-4R-bearing human brain cancer cells. Preclinical toxicologic experiments were performed in mice, rats, and guinea pigs to determine an maximum tolerated dose. Intrathecal administration in cynomolgus monkeys produced high cerebrospinal fluid levels without any central nervous system or other abnormalities. When IL4-PE was injected into the right frontal cortex of rats, localized necrosis was observed at 1,000 but not < or =100 microg/ml doses. Intravenous administration of this biologic to monkeys produced reversible grade 3 or grade 4 elevations of hepatic enzymes in a dose-dependent manner. These results indicate that localized administration can produce nontoxic levels of IL4-PE that may have significant activity against astrocytoma. In vivo experiments with nude mice have demonstrated that IL4-PE has significant antitumor activity against human glioblastoma tumor model. Intratumor administration of IL4-PE has been initiated for the treatment of malignant astrocytoma in a phase I clinical trial." @default.
- W2024101024 created "2016-06-24" @default.
- W2024101024 creator A5067972591 @default.
- W2024101024 date "1999-01-01" @default.
- W2024101024 modified "2023-10-14" @default.
- W2024101024 title "Toxicologic Pathology of Cytokines, Cytokine Receptors, and Other Recombinant Human Proteins" @default.
- W2024101024 cites W1240277104 @default.
- W2024101024 cites W1519570339 @default.
- W2024101024 cites W1567604499 @default.
- W2024101024 cites W1958440406 @default.
- W2024101024 cites W1971500432 @default.
- W2024101024 cites W1983844193 @default.
- W2024101024 cites W1991036896 @default.
- W2024101024 cites W2021820438 @default.
- W2024101024 cites W2029102977 @default.
- W2024101024 cites W2029428013 @default.
- W2024101024 cites W2035544432 @default.
- W2024101024 cites W2037342239 @default.
- W2024101024 cites W2045575773 @default.
- W2024101024 cites W2070629020 @default.
- W2024101024 cites W2084228983 @default.
- W2024101024 cites W2084580821 @default.
- W2024101024 cites W2135757997 @default.
- W2024101024 cites W2140612321 @default.
- W2024101024 cites W2177651721 @default.
- W2024101024 cites W2181523762 @default.
- W2024101024 cites W2190356106 @default.
- W2024101024 cites W2255965873 @default.
- W2024101024 cites W4235751459 @default.
- W2024101024 doi "https://doi.org/10.1177/019262339902700111" @default.
- W2024101024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10367674" @default.
- W2024101024 hasPublicationYear "1999" @default.
- W2024101024 type Work @default.
- W2024101024 sameAs 2024101024 @default.
- W2024101024 citedByCount "36" @default.
- W2024101024 countsByYear W20241010242012 @default.
- W2024101024 countsByYear W20241010242013 @default.
- W2024101024 countsByYear W20241010242014 @default.
- W2024101024 countsByYear W20241010242015 @default.
- W2024101024 countsByYear W20241010242016 @default.
- W2024101024 countsByYear W20241010242019 @default.
- W2024101024 countsByYear W20241010242020 @default.
- W2024101024 countsByYear W20241010242022 @default.
- W2024101024 crossrefType "journal-article" @default.
- W2024101024 hasAuthorship W2024101024A5067972591 @default.
- W2024101024 hasConcept C115085202 @default.
- W2024101024 hasConcept C126322002 @default.
- W2024101024 hasConcept C142724271 @default.
- W2024101024 hasConcept C159654299 @default.
- W2024101024 hasConcept C170493617 @default.
- W2024101024 hasConcept C203014093 @default.
- W2024101024 hasConcept C2778227246 @default.
- W2024101024 hasConcept C2778690821 @default.
- W2024101024 hasConcept C2778880634 @default.
- W2024101024 hasConcept C502942594 @default.
- W2024101024 hasConcept C529278444 @default.
- W2024101024 hasConcept C542903549 @default.
- W2024101024 hasConcept C71924100 @default.
- W2024101024 hasConcept C86803240 @default.
- W2024101024 hasConcept C98274493 @default.
- W2024101024 hasConceptScore W2024101024C115085202 @default.
- W2024101024 hasConceptScore W2024101024C126322002 @default.
- W2024101024 hasConceptScore W2024101024C142724271 @default.
- W2024101024 hasConceptScore W2024101024C159654299 @default.
- W2024101024 hasConceptScore W2024101024C170493617 @default.
- W2024101024 hasConceptScore W2024101024C203014093 @default.
- W2024101024 hasConceptScore W2024101024C2778227246 @default.
- W2024101024 hasConceptScore W2024101024C2778690821 @default.
- W2024101024 hasConceptScore W2024101024C2778880634 @default.
- W2024101024 hasConceptScore W2024101024C502942594 @default.
- W2024101024 hasConceptScore W2024101024C529278444 @default.
- W2024101024 hasConceptScore W2024101024C542903549 @default.
- W2024101024 hasConceptScore W2024101024C71924100 @default.
- W2024101024 hasConceptScore W2024101024C86803240 @default.
- W2024101024 hasConceptScore W2024101024C98274493 @default.
- W2024101024 hasIssue "1" @default.
- W2024101024 hasLocation W20241010241 @default.
- W2024101024 hasLocation W20241010242 @default.
- W2024101024 hasOpenAccess W2024101024 @default.
- W2024101024 hasPrimaryLocation W20241010241 @default.
- W2024101024 hasRelatedWork W2013077767 @default.
- W2024101024 hasRelatedWork W2103278475 @default.
- W2024101024 hasRelatedWork W2106443011 @default.
- W2024101024 hasRelatedWork W2108312517 @default.
- W2024101024 hasRelatedWork W2108398384 @default.
- W2024101024 hasRelatedWork W2111618277 @default.
- W2024101024 hasRelatedWork W2139816948 @default.
- W2024101024 hasRelatedWork W2154649938 @default.
- W2024101024 hasRelatedWork W2972075105 @default.
- W2024101024 hasRelatedWork W3028962486 @default.
- W2024101024 hasVolume "27" @default.
- W2024101024 isParatext "false" @default.
- W2024101024 isRetracted "false" @default.
- W2024101024 magId "2024101024" @default.
- W2024101024 workType "article" @default.