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• W2024101399 abstract "The fine immunoreactivity of the rabbit humoral response elicited by four env-recombinant avipoxviruses and their ability to stimulate a memory T-cell response and a protective immunity have been studied. The antibody specificity was compared with the serum neutralizing activity and virus-specific T-cell proliferative response. Resistance to challenge by cell-associated HIV-1 was monitored by PCR. Canarypox (CP) and fowlpox (FP) constructs, containing the complete env gene (IS(+)) from the HIV-1(SF2) strain, induced a higher profile of epitope recognition than their counterparts expressing the env gene deleted of the putative immunosuppressive region (IS(-)). Serum neutralizing activity was in agreement with fusion inhibition and lymphoproliferative response in rabbits immunized with CPIS(+), and only partially with FPIS(+). Rabbits failed to be infected, but anti- p55 gag-specific antibodies could be demonstrated by Western blot. This study confirms the ability of these non-replicative live recombinant viruses to elicit a complete immune response, capable of inhibiting specific HIV-1 functions." @default.
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• W2024101399 date "2000-03-01" @default.
• W2024101399 modified "2023-09-23" @default.
• W2024101399 title "Correlation between the immune response elicited in rabbits byenv-recombinant avipox vaccines and the inhibition of HIV-1-specific functions" @default.
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• W2024101399 doi "https://doi.org/10.1111/j.1574-695x.2000.tb01432.x" @default.
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