FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024101480> ?p ?o ?g. }

• W2024101480 endingPage "197" @default.
• W2024101480 startingPage "185" @default.
• W2024101480 abstract "Mycobacterium avium-intracellulare complex (MAI) are common pathogens of opportunistic infections that are naturally resistant to most antibiotics and develop acquired resistance rapidly. An experimental drug, poloxamer CRL-1072, was found to have two unusual properties: it synergistically enhanced the activity of several antibiotics against MAI even though it had little activity as a single agent and it had greater activity against MAI in macrophage culture or in mice than in broth culture. Studies were undertaken to investigate the mechanisms of these effects. CRL-1072 was taken up by MAI and enhanced the uptake of fluorescent-labeled streptomycin and erythromycin in broth culture. The labeled antibiotics had reduced activity so the relevance for naive antibiotics must be inferred. In culture with human U937 monocytoid cells, CRL-1072 became localized in phagosomes and promoted uptake of streptomycin. Finally, CRL-1072 was found to induce production of mRNA for inducible nitric oxide synthase (iNOS) and nitric oxide (NO) by U937 cells. The antimycobacterial effect in macrophages was reversed by the iNOS inhibitor N-monomethyl L-arginine (NMMA), suggesting that CRL-1072 promotes killing of MAI by inducing NO. These effects were induced by noncytotoxic concentrations of CRL-1072. These data suggest that the antimycobacterial mechanisms of CRL-1072 include enhancing the delivery of antibiotic to targets within MAI and enhancement of the ability of macrophages to kill ingested organisms." @default.
• W2024101480 created "2016-06-24" @default.
• W2024101480 creator A5010912348 @default.
• W2024101480 creator A5032429713 @default.
• W2024101480 creator A5050221150 @default.
• W2024101480 creator A5058926050 @default.
• W2024101480 creator A5077775717 @default.
• W2024101480 creator A5082783597 @default.
• W2024101480 date "2000-07-01" @default.
• W2024101480 modified "2023-09-25" @default.
• W2024101480 title "Effect of poloxamer CRL-1072 on drug uptake and nitric-oxide-mediated killing of Mycobacterium avium by macrophages" @default.
• W2024101480 cites W1502243809 @default.
• W2024101480 cites W1504045286 @default.
• W2024101480 cites W1529380952 @default.
• W2024101480 cites W1585845642 @default.
• W2024101480 cites W1587195158 @default.
• W2024101480 cites W1591354332 @default.
• W2024101480 cites W1600281413 @default.
• W2024101480 cites W1839414573 @default.
• W2024101480 cites W1892147813 @default.
• W2024101480 cites W1895129045 @default.
• W2024101480 cites W1903515437 @default.
• W2024101480 cites W1910381255 @default.
• W2024101480 cites W1912051890 @default.
• W2024101480 cites W1966492806 @default.
• W2024101480 cites W1967255828 @default.
• W2024101480 cites W1967384913 @default.
• W2024101480 cites W1977322085 @default.
• W2024101480 cites W1977716290 @default.
• W2024101480 cites W1995223285 @default.
• W2024101480 cites W2000495523 @default.
• W2024101480 cites W2018616596 @default.
• W2024101480 cites W2026128471 @default.
• W2024101480 cites W2052965405 @default.
• W2024101480 cites W2061602151 @default.
• W2024101480 cites W2075317347 @default.
• W2024101480 cites W2078658984 @default.
• W2024101480 cites W2078785671 @default.
• W2024101480 cites W2090226113 @default.
• W2024101480 cites W2092392703 @default.
• W2024101480 cites W2098695824 @default.
• W2024101480 cites W2106726937 @default.
• W2024101480 cites W2121941042 @default.
• W2024101480 cites W2129710335 @default.
• W2024101480 cites W2135968643 @default.
• W2024101480 cites W2140301468 @default.
• W2024101480 cites W2140382751 @default.
• W2024101480 cites W2140479700 @default.
• W2024101480 cites W2141475535 @default.
• W2024101480 cites W2144345256 @default.
• W2024101480 cites W2145896966 @default.
• W2024101480 cites W2147251439 @default.
• W2024101480 cites W2152639661 @default.
• W2024101480 cites W2169140191 @default.
• W2024101480 cites W97745916 @default.
• W2024101480 cites W1993884839 @default.
• W2024101480 doi "https://doi.org/10.1016/s0162-3109(00)00203-4" @default.
• W2024101480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10936516" @default.
• W2024101480 hasPublicationYear "2000" @default.
• W2024101480 type Work @default.
• W2024101480 sameAs 2024101480 @default.
• W2024101480 citedByCount "8" @default.
• W2024101480 countsByYear W20241014802017 @default.
• W2024101480 countsByYear W20241014802021 @default.
• W2024101480 countsByYear W20241014802023 @default.
• W2024101480 crossrefType "journal-article" @default.
• W2024101480 hasAuthorship W2024101480A5010912348 @default.
• W2024101480 hasAuthorship W2024101480A5032429713 @default.
• W2024101480 hasAuthorship W2024101480A5050221150 @default.
• W2024101480 hasAuthorship W2024101480A5058926050 @default.
• W2024101480 hasAuthorship W2024101480A5077775717 @default.
• W2024101480 hasAuthorship W2024101480A5082783597 @default.
• W2024101480 hasConcept C142724271 @default.
• W2024101480 hasConcept C178790620 @default.
• W2024101480 hasConcept C185592680 @default.
• W2024101480 hasConcept C202751555 @default.
• W2024101480 hasConcept C2775843808 @default.
• W2024101480 hasConcept C2777975735 @default.
• W2024101480 hasConcept C2779244956 @default.
• W2024101480 hasConcept C2779685592 @default.
• W2024101480 hasConcept C2780374374 @default.
• W2024101480 hasConcept C2781069245 @default.
• W2024101480 hasConcept C501593827 @default.
• W2024101480 hasConcept C519581460 @default.
• W2024101480 hasConcept C523546767 @default.
• W2024101480 hasConcept C54355233 @default.
• W2024101480 hasConcept C55493867 @default.
• W2024101480 hasConcept C71924100 @default.
• W2024101480 hasConcept C86803240 @default.
• W2024101480 hasConcept C89423630 @default.
• W2024101480 hasConcept C98274493 @default.
• W2024101480 hasConceptScore W2024101480C142724271 @default.
• W2024101480 hasConceptScore W2024101480C178790620 @default.
• W2024101480 hasConceptScore W2024101480C185592680 @default.
• W2024101480 hasConceptScore W2024101480C202751555 @default.
• W2024101480 hasConceptScore W2024101480C2775843808 @default.
• W2024101480 hasConceptScore W2024101480C2777975735 @default.
• W2024101480 hasConceptScore W2024101480C2779244956 @default.

• next