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• W2024103170 abstract "The p53 tumor suppressor responds to chemotherapeutic stress by triggering apoptosis or eliciting pro-survival pathway through arresting cell cycle progression for DNA damage repair. Here we examined the pro-survival activity of p53 on the adriamycin-induced stress using H1299 cells stably expressing tsp53 V143A, a temperature-sensitive mutant activating only the subset of p53 target genes related to growth arrest and DNA repair, but not apoptosis. At 38 degrees C, cells evaded from adriamycin-induced G2 arrest and died of apoptosis and mitotic catastrophe, which could be inhibited by Cdk inhibitors. Activation of functional tsp53 V143A at 32 degrees C led to suppression of Cdk1/2 activities and Cyclin B1/Cdk1 expression, cells exhibited prolonged G2 arrest, regained reproductive potential and were protected from mitotic catastrophe induced by adriamycin. Inhibition of mitotic catastrophe and Cyclin B1/Cdk1 expression was ablated upon silencing p21 Waf1 expression in tsp53 V143A-H1299 cells or in HCT116 cells. Together we show that p21 Waf1 is a key component of G2 checkpoint necessary and sufficient for protecting tumor cells against adriamycin-induced mitotic catastrophe." @default.
• W2024103170 created "2016-06-24" @default.
• W2024103170 creator A5020748322 @default.
• W2024103170 creator A5091220699 @default.
• W2024103170 date "2008-01-01" @default.
• W2024103170 modified "2023-09-25" @default.
• W2024103170 title "Mechanisms underlying the pro-survival pathway of p53 in suppressing mitotic death induced by adriamycin" @default.
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• W2024103170 doi "https://doi.org/10.1016/j.cellsig.2007.10.017" @default.
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