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- W2024105404 abstract "Central venous catheters (CVCs) are responsible for approximately 90% of all catheter-related bloodstream infections (CRBSIs). The resulting 300,000 infections, commonly caused by Staphylococcus aureus and Staphylococcus epidermidis, are associated with as many as 28,000 deaths per year in America alone. CRBSIs prolong hospital stays, induce human suffering, and magnify healthcare costs (up to $2.68 billion). Infection is four times more likely to occur in patients with catheter-related thrombosis (CRT), and up to 67% of patients with CVC develop CRT. A common strategy used to prevent CRBSIs has been to impregnate CVCs with antimicrobial agents to control microbial colonization, and heparin coatings to prevent CRT. These strategies can be limited by the short duration of efficacy and the potential for contributing to antimicrobial resistance and heparin induced safety concerns. A novel micro-topography (Figure 1, bottom panels) may provide an alternative strategy as it has been shown to reduce bacterial attachment and biofilm formation without the use of antimicrobial agents. This biomimetic micro-pattern also inhibits bacterial migration, offering the possibility of reducing bacterial access into the bloodstream via the CVC. The objectives of this study were to determine the performance of the micro-pattern in reducing S. aureus attachment after whole blood pre-conditioning and to evaluate the innate anti-fouling properties the pattern may have in reducing platelet attachment and aggregation, precursors to thrombosis that can lead to CRT related CRBSIs." @default.
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- W2024105404 date "2012-06-01" @default.
- W2024105404 modified "2023-09-27" @default.
- W2024105404 title "Micro-Patterned Surfaces for Reducing Platelet Adhesion and Bacterial Attachment Associated With Catheter-Associated Blood Stream Infections" @default.
- W2024105404 doi "https://doi.org/10.1016/j.ajic.2012.04.099" @default.
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