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• W2024108377 abstract "Mice carrying a knock-in mutation (Phe377del) in the Ank gene replicate many skeletal characteristics of human craniometaphyseal dysplasia, including hyperostotic mandibles. Ank KI/KI mice have normal morphology of erupted molars and incisors but excessive cementum deposition with increased numbers of Ibsp- and Dmp1-positive cells on root surfaces. The cervical loops of adult Ank KI/KI lower incisors are at the level of the third molars, while they are close to the mandibular foramen in Ank +/+ mice. Furthermore, Ank KI/KI incisors show decreased eruption rates, decreased proliferation of odontoblast precursors, and increased cell apoptosis in the stellate reticulum. However, their capability for continuous elongation is not compromised. Quantification of TRAP-positive cells in the apical ends of Ank KI/KI incisors revealed decreased osteoclast numbers and osteoclast surfaces. Bisphosphonate injections in Ank +/+ mice replicate the Ank KI/KI incisor phenotype. These results and a comparison with the dental phenotype of Ank loss-of-function mouse models suggest that increased cementum thickness may be caused by decreased extracellular PPi levels and that the incisor phenotype is likely due to hyperostosis of mandibles, which distinguishes Ank KI/KI mice from the other Ank mouse models." @default.
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• W2024108377 date "2012-11-15" @default.
• W2024108377 modified "2023-09-30" @default.
• W2024108377 title "Dental Abnormalities in a Mouse Model for Craniometaphyseal Dysplasia" @default.
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• W2024108377 doi "https://doi.org/10.1177/0022034512468157" @default.
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