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• W2024116142 abstract "Variation in couplon size is thought to be essential for graded Ca(2+) transients in cardiac myocytes. We examined this variation by investigating spark appearance in rabbit ventricular myocytes at various locations and at potentials from -20 to 0 mV. At 0 mV, sparks appeared at the beginning of the voltage step with a probability of unity. On the other hand, at -20 mV, sparks appeared later during the voltage step with a lower probability. The cumulative spark probabilities at various potentials were fitted with exponential functions of both time and voltage. Spark latency became longer as spark probability decreased at more negative potentials. At -20 mV, the cumulative spark probability and the mean spark latency were not only variable among locations but also inversely related. Under the assumption that a single opening of an L-type Ca(2+) channel triggers a spark, we suggest a simple mathematical explanation for the distribution of spark appearance. The variation in spark probability and latency with location suggests that the couplon size, and hence the number of L-type Ca(2+) channels in a couplon is variable." @default.
• W2024116142 created "2016-06-24" @default.
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• W2024116142 date "2005-11-01" @default.
• W2024116142 modified "2023-10-02" @default.
• W2024116142 title "Variability in Couplon Size in Rabbit Ventricular Myocytes" @default.
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• W2024116142 doi "https://doi.org/10.1529/biophysj.105.065862" @default.
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