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- W2024119654 endingPage "84" @default.
- W2024119654 startingPage "73" @default.
- W2024119654 abstract "Epithelial cells usually exist as sheets of immotile, tightly packed, well-coupled, polarized cells with distinct apical, basal and lateral surfaces. Remarkably, these cells can dramatically alter their morphology to become motile, fibroblast-like mesenchymal cells in a process of epithelial-mesenchymal transition (EMT). This process and the reverse, mesenchymal-epithelial transition, occur repeatedly during normal embryonic development. A phenomenon similar to physiological EMT occurs during the pathophysiological progression of some cancers. Tumours of epithelial origin, as they transform to malignancy, appear to exploit the innate plasticity of epithelial cells, with EMT conferring increased invasiveness and metastatic potential. Key to the maintenance of epithelial cell identity is the expression of E-cadherin, a protein that is required for tight intercellular adhesion along the lateral surfaces of adjacent epithelial cells. Loss of functional E-cadherin is a critical event in EMT. An important regulator of E-cadherin expression is the protein Snail, a zinc-finger transcriptional repressor. Snail contains several consensus sites for the kinase, glycogen synthase kinase-3 (GSK-3), and accumulating evidence indicates that it is a GSK-3 substrate. Phosphorylation of Snail by GSK-3 facilitates its proteasomal degradation. Conversely, inhibition of GSK-3 leads to Snail accumulation, E-cadherin downregulation, and development of EMT in cultured epithelial cells. Several signalling pathways implicated in the progression of EMT, including the Wnt and phosphoinositide 3-kinase pathways, use GSK-3 to mediate their responses. In these pathways, GSK-3’s regulation of other transcriptional effectors like β-catenin works in concert with changes in Snail to orchestrate the EMT process. This review focuses on the emerging role of GSK-3 as a modulator of cell fate and EMT in the contexts of development, in vitro cell culture and cancer." @default.
- W2024119654 created "2016-06-24" @default.
- W2024119654 creator A5043927370 @default.
- W2024119654 creator A5052689605 @default.
- W2024119654 date "2007-01-01" @default.
- W2024119654 modified "2023-10-03" @default.
- W2024119654 title "Role of Glycogen Synthase Kinase-3 in Cell Fate and Epithelial-Mesenchymal Transitions" @default.
- W2024119654 cites W117902596 @default.
- W2024119654 cites W126765507 @default.
- W2024119654 cites W1480706413 @default.
- W2024119654 cites W1504655784 @default.
- W2024119654 cites W1506031925 @default.
- W2024119654 cites W1544465315 @default.
- W2024119654 cites W1635607892 @default.
- W2024119654 cites W1653014745 @default.
- W2024119654 cites W1857109061 @default.
- W2024119654 cites W1864386522 @default.
- W2024119654 cites W1908612571 @default.
- W2024119654 cites W1911954838 @default.
- W2024119654 cites W1964631519 @default.
- W2024119654 cites W1971689970 @default.
- W2024119654 cites W1972343960 @default.
- W2024119654 cites W1973647487 @default.
- W2024119654 cites W1973890143 @default.
- W2024119654 cites W1976320711 @default.
- W2024119654 cites W1983055247 @default.
- W2024119654 cites W1983985302 @default.
- W2024119654 cites W1987473368 @default.
- W2024119654 cites W1990201193 @default.
- W2024119654 cites W1994242450 @default.
- W2024119654 cites W1995480433 @default.
- W2024119654 cites W1997321621 @default.
- W2024119654 cites W1997345969 @default.
- W2024119654 cites W1998556995 @default.
- W2024119654 cites W1998777048 @default.
- W2024119654 cites W2003637983 @default.
- W2024119654 cites W2004922458 @default.
- W2024119654 cites W2005782838 @default.
- W2024119654 cites W2006417453 @default.
- W2024119654 cites W2007752398 @default.
- W2024119654 cites W2007780733 @default.
- W2024119654 cites W2008221746 @default.
- W2024119654 cites W2013460988 @default.
- W2024119654 cites W2015839591 @default.
- W2024119654 cites W2016273963 @default.
- W2024119654 cites W2017593144 @default.
- W2024119654 cites W2017862163 @default.
- W2024119654 cites W2019041110 @default.
- W2024119654 cites W2021345837 @default.
- W2024119654 cites W2021522625 @default.
- W2024119654 cites W2021526208 @default.
- W2024119654 cites W2022309233 @default.
- W2024119654 cites W2023537681 @default.
- W2024119654 cites W2024451865 @default.
- W2024119654 cites W2026158123 @default.
- W2024119654 cites W2032930150 @default.
- W2024119654 cites W2034270890 @default.
- W2024119654 cites W2036008499 @default.
- W2024119654 cites W2036836052 @default.
- W2024119654 cites W2039193100 @default.
- W2024119654 cites W2043377295 @default.
- W2024119654 cites W2044215253 @default.
- W2024119654 cites W2045947221 @default.
- W2024119654 cites W2046447415 @default.
- W2024119654 cites W2047992261 @default.
- W2024119654 cites W2049881581 @default.
- W2024119654 cites W2055007848 @default.
- W2024119654 cites W2058138221 @default.
- W2024119654 cites W2059030354 @default.
- W2024119654 cites W2061170173 @default.
- W2024119654 cites W2063712660 @default.
- W2024119654 cites W2066497759 @default.
- W2024119654 cites W2069021156 @default.
- W2024119654 cites W2071018297 @default.
- W2024119654 cites W2072008436 @default.
- W2024119654 cites W2076583198 @default.
- W2024119654 cites W2076892771 @default.
- W2024119654 cites W2078576765 @default.
- W2024119654 cites W2082387343 @default.
- W2024119654 cites W2082905439 @default.
- W2024119654 cites W2083308747 @default.
- W2024119654 cites W2088568448 @default.
- W2024119654 cites W2093905004 @default.
- W2024119654 cites W2095202492 @default.
- W2024119654 cites W2098802640 @default.
- W2024119654 cites W2100269253 @default.
- W2024119654 cites W2102298903 @default.
- W2024119654 cites W2104856326 @default.
- W2024119654 cites W2108707301 @default.
- W2024119654 cites W2111113377 @default.
- W2024119654 cites W2112763851 @default.
- W2024119654 cites W2119284420 @default.
- W2024119654 cites W2120657906 @default.
- W2024119654 cites W2124852687 @default.
- W2024119654 cites W2125053924 @default.
- W2024119654 cites W2129124145 @default.
- W2024119654 cites W2131686724 @default.
- W2024119654 cites W2132475598 @default.