FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024125635> ?p ?o ?g. }

• W2024125635 endingPage "186" @default.
• W2024125635 startingPage "177" @default.
• W2024125635 abstract "Androgen receptor (AR) levels are regulated by androgens, other steroids and non-steroidal hormones via complex, tissue-specific processes. Since alterations in receptor levels may influence cellular sensitivity to androgens, understanding AR regulation is of fundamental and potentially therapeutic significance. In most target tissues and AR-containing cell lines, AR mRNA is down-regulated in response to androgens. We have reconstituted this androgen-mediated down-regulation of AR mRNA in COS 1 cells transfected with a human AR cDNA under the control of the cytomegalovirus (CMV) promoter. The sequences mediating receptor mRNA down-regulation are represented within the AR cDNA and not within the CMV promoter. Androgenic down-regulation of AR cDNA expression was time- and dose-dependent, resembling native AR mRNA down-regulation. In addition, androgenic regulation of the receptor cDNA was not dependent on protein synthesis suggesting that AR and/or another pre-existing protein(s) is involved in this process. In COS 1 cells co-transfected with androgen and glucocorticoid receptor cDNAs, dexamethasone mimicked the action of androgen in down-regulating AR mRNA. This response depended on glucocorticoid receptors. Androgen had little effect on steady-state levels of AR protein consistent with reports that androgen down-regulates AR mRNA but increases AR protein half-life (Kemppainen et al. (1992) J. Biol. Chem. 267, 968-974; Zhou et al. (1995) Mol. Endocrinol. 9, 208-218). However, glucocorticoids decreased AR protein levels in cells that co-expressed androgen and glucocorticoid receptors. These results indicate that sequences represented in the AR cDNA mediate AR mRNA down-regulation by both androgens and glucocorticoids. Inhibition of AR mRNA and protein by glucocorticoids suggests that these steroids may modulate androgen action in tissues, such as mammary gland and prostate, which express both androgen and glucocorticoid receptors." @default.
• W2024125635 created "2016-06-24" @default.
• W2024125635 creator A5047527114 @default.
• W2024125635 creator A5064088146 @default.
• W2024125635 creator A5088558562 @default.
• W2024125635 creator A5090599896 @default.
• W2024125635 date "1995-12-01" @default.
• W2024125635 modified "2023-09-27" @default.
• W2024125635 title "Androgen and glucocorticoid regulation of androgen receptor cDNA expression" @default.
• W2024125635 cites W1484666375 @default.
• W2024125635 cites W1495912963 @default.
• W2024125635 cites W1500649719 @default.
• W2024125635 cites W1573981241 @default.
• W2024125635 cites W1601561275 @default.
• W2024125635 cites W1775749144 @default.
• W2024125635 cites W1963652838 @default.
• W2024125635 cites W1983885442 @default.
• W2024125635 cites W2019818723 @default.
• W2024125635 cites W2027586930 @default.
• W2024125635 cites W2028206154 @default.
• W2024125635 cites W2036006424 @default.
• W2024125635 cites W2052244410 @default.
• W2024125635 cites W205313094 @default.
• W2024125635 cites W2054839740 @default.
• W2024125635 cites W2055156961 @default.
• W2024125635 cites W2055917202 @default.
• W2024125635 cites W2059051245 @default.
• W2024125635 cites W2060333964 @default.
• W2024125635 cites W2060903877 @default.
• W2024125635 cites W2066570340 @default.
• W2024125635 cites W2072865274 @default.
• W2024125635 cites W2076288865 @default.
• W2024125635 cites W2090833138 @default.
• W2024125635 cites W2095348706 @default.
• W2024125635 cites W2095417126 @default.
• W2024125635 cites W2096491966 @default.
• W2024125635 cites W2110953868 @default.
• W2024125635 cites W2128840922 @default.
• W2024125635 cites W2129688020 @default.
• W2024125635 cites W2131916833 @default.
• W2024125635 cites W2144115729 @default.
• W2024125635 cites W2156184907 @default.
• W2024125635 cites W2159723327 @default.
• W2024125635 cites W2162588777 @default.
• W2024125635 doi "https://doi.org/10.1016/0303-7207(95)03688-1" @default.
• W2024125635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8824893" @default.
• W2024125635 hasPublicationYear "1995" @default.
• W2024125635 type Work @default.
• W2024125635 sameAs 2024125635 @default.
• W2024125635 citedByCount "71" @default.
• W2024125635 countsByYear W20241256352012 @default.
• W2024125635 countsByYear W20241256352013 @default.
• W2024125635 countsByYear W20241256352014 @default.
• W2024125635 countsByYear W20241256352015 @default.
• W2024125635 countsByYear W20241256352016 @default.
• W2024125635 countsByYear W20241256352017 @default.
• W2024125635 countsByYear W20241256352018 @default.
• W2024125635 countsByYear W20241256352019 @default.
• W2024125635 countsByYear W20241256352020 @default.
• W2024125635 countsByYear W20241256352021 @default.
• W2024125635 countsByYear W20241256352022 @default.
• W2024125635 crossrefType "journal-article" @default.
• W2024125635 hasAuthorship W2024125635A5047527114 @default.
• W2024125635 hasAuthorship W2024125635A5064088146 @default.
• W2024125635 hasAuthorship W2024125635A5088558562 @default.
• W2024125635 hasAuthorship W2024125635A5090599896 @default.
• W2024125635 hasBestOaLocation W20241256351 @default.
• W2024125635 hasConcept C104317684 @default.
• W2024125635 hasConcept C105580179 @default.
• W2024125635 hasConcept C121608353 @default.
• W2024125635 hasConcept C126322002 @default.
• W2024125635 hasConcept C134018914 @default.
• W2024125635 hasConcept C153911025 @default.
• W2024125635 hasConcept C170493617 @default.
• W2024125635 hasConcept C187882448 @default.
• W2024125635 hasConcept C2777911890 @default.
• W2024125635 hasConcept C2780192828 @default.
• W2024125635 hasConcept C2780841215 @default.
• W2024125635 hasConcept C54009773 @default.
• W2024125635 hasConcept C54355233 @default.
• W2024125635 hasConcept C55493867 @default.
• W2024125635 hasConcept C59493245 @default.
• W2024125635 hasConcept C61367390 @default.
• W2024125635 hasConcept C71315377 @default.
• W2024125635 hasConcept C71924100 @default.
• W2024125635 hasConcept C81885089 @default.
• W2024125635 hasConcept C86803240 @default.
• W2024125635 hasConceptScore W2024125635C104317684 @default.
• W2024125635 hasConceptScore W2024125635C105580179 @default.
• W2024125635 hasConceptScore W2024125635C121608353 @default.
• W2024125635 hasConceptScore W2024125635C126322002 @default.
• W2024125635 hasConceptScore W2024125635C134018914 @default.
• W2024125635 hasConceptScore W2024125635C153911025 @default.
• W2024125635 hasConceptScore W2024125635C170493617 @default.
• W2024125635 hasConceptScore W2024125635C187882448 @default.
• W2024125635 hasConceptScore W2024125635C2777911890 @default.
• W2024125635 hasConceptScore W2024125635C2780192828 @default.
• W2024125635 hasConceptScore W2024125635C2780841215 @default.

• next