FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024128181> ?p ?o ?g. }

• W2024128181 endingPage "236" @default.
• W2024128181 startingPage "223" @default.
• W2024128181 abstract "Proteins can perform completely distinct functions in response to the particular partners that they bind to. Consequently, determination of the mechanism of functional regulation in such systems requires elucidation of the mechanism switching between binding partners. The central protein of the Escherichia coli biotin regulatory system, BirA, switches between its function as a metabolic enzyme or a transcriptional repressor in response to binding either the biotin carboxyl carrier protein subunit of acetyl-CoA carboxylase or a second BirA monomer. These two protein–protein interactions are structurally mutually exclusive. The results of earlier studies suggest that the system is regulated by kinetic partitioning between the two protein–protein interactions. In this work, sedimentation velocity was employed to monitor the partitioning directly. The results indicate similar equilibrium parameters governing formation of the two protein–protein interactions. Kinetic analysis of the sedimentation velocity data indicated that holoBirA dimerization is governed by very slow forward and reverse rate constants. The slow kinetics of holoBirA dimerization combined with fluctuations in the intracellular apoBCCP pool are critical determinants in partitioning BirA between its distinct biological functions." @default.
• W2024128181 created "2016-06-24" @default.
• W2024128181 creator A5054568408 @default.
• W2024128181 creator A5066962035 @default.
• W2024128181 date "2008-06-01" @default.
• W2024128181 modified "2023-09-28" @default.
• W2024128181 title "Kinetic Partitioning Between Alternative Protein–Protein Interactions Controls a Transcriptional Switch" @default.
• W2024128181 cites W1521470590 @default.
• W2024128181 cites W1536505229 @default.
• W2024128181 cites W1565197201 @default.
• W2024128181 cites W1693871300 @default.
• W2024128181 cites W1763161027 @default.
• W2024128181 cites W1889501894 @default.
• W2024128181 cites W1967585585 @default.
• W2024128181 cites W1968174724 @default.
• W2024128181 cites W1975317507 @default.
• W2024128181 cites W1978935359 @default.
• W2024128181 cites W1986811464 @default.
• W2024128181 cites W1988226018 @default.
• W2024128181 cites W1989492050 @default.
• W2024128181 cites W1999746361 @default.
• W2024128181 cites W2001829368 @default.
• W2024128181 cites W2002184253 @default.
• W2024128181 cites W2002195659 @default.
• W2024128181 cites W2010392743 @default.
• W2024128181 cites W2012928763 @default.
• W2024128181 cites W2013841244 @default.
• W2024128181 cites W2018961364 @default.
• W2024128181 cites W2027757950 @default.
• W2024128181 cites W2029095216 @default.
• W2024128181 cites W2031393760 @default.
• W2024128181 cites W2032660941 @default.
• W2024128181 cites W2049498055 @default.
• W2024128181 cites W2053802188 @default.
• W2024128181 cites W2054885257 @default.
• W2024128181 cites W2058355519 @default.
• W2024128181 cites W2061645385 @default.
• W2024128181 cites W2075730531 @default.
• W2024128181 cites W2083576886 @default.
• W2024128181 cites W2085137948 @default.
• W2024128181 cites W2097410482 @default.
• W2024128181 cites W2124283003 @default.
• W2024128181 cites W2142396509 @default.
• W2024128181 cites W2160039306 @default.
• W2024128181 cites W2168189558 @default.
• W2024128181 cites W25393236 @default.
• W2024128181 cites W4234608772 @default.
• W2024128181 doi "https://doi.org/10.1016/j.jmb.2008.04.068" @default.
• W2024128181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2566847" @default.
• W2024128181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18508076" @default.
• W2024128181 hasPublicationYear "2008" @default.
• W2024128181 type Work @default.
• W2024128181 sameAs 2024128181 @default.
• W2024128181 citedByCount "34" @default.
• W2024128181 countsByYear W20241281812012 @default.
• W2024128181 countsByYear W20241281812013 @default.
• W2024128181 countsByYear W20241281812014 @default.
• W2024128181 countsByYear W20241281812015 @default.
• W2024128181 countsByYear W20241281812016 @default.
• W2024128181 countsByYear W20241281812017 @default.
• W2024128181 countsByYear W20241281812018 @default.
• W2024128181 countsByYear W20241281812019 @default.
• W2024128181 countsByYear W20241281812022 @default.
• W2024128181 crossrefType "journal-article" @default.
• W2024128181 hasAuthorship W2024128181A5054568408 @default.
• W2024128181 hasAuthorship W2024128181A5066962035 @default.
• W2024128181 hasBestOaLocation W20241281812 @default.
• W2024128181 hasConcept C104292427 @default.
• W2024128181 hasConcept C104317684 @default.
• W2024128181 hasConcept C11804247 @default.
• W2024128181 hasConcept C121332964 @default.
• W2024128181 hasConcept C12554922 @default.
• W2024128181 hasConcept C140137476 @default.
• W2024128181 hasConcept C14036430 @default.
• W2024128181 hasConcept C148898269 @default.
• W2024128181 hasConcept C150194340 @default.
• W2024128181 hasConcept C158448853 @default.
• W2024128181 hasConcept C181199279 @default.
• W2024128181 hasConcept C185592680 @default.
• W2024128181 hasConcept C2778204606 @default.
• W2024128181 hasConcept C51639874 @default.
• W2024128181 hasConcept C55493867 @default.
• W2024128181 hasConcept C62520636 @default.
• W2024128181 hasConcept C86803240 @default.
• W2024128181 hasConcept C95444343 @default.
• W2024128181 hasConceptScore W2024128181C104292427 @default.
• W2024128181 hasConceptScore W2024128181C104317684 @default.
• W2024128181 hasConceptScore W2024128181C11804247 @default.
• W2024128181 hasConceptScore W2024128181C121332964 @default.
• W2024128181 hasConceptScore W2024128181C12554922 @default.
• W2024128181 hasConceptScore W2024128181C140137476 @default.
• W2024128181 hasConceptScore W2024128181C14036430 @default.
• W2024128181 hasConceptScore W2024128181C148898269 @default.
• W2024128181 hasConceptScore W2024128181C150194340 @default.
• W2024128181 hasConceptScore W2024128181C158448853 @default.
• W2024128181 hasConceptScore W2024128181C181199279 @default.
• W2024128181 hasConceptScore W2024128181C185592680 @default.
• W2024128181 hasConceptScore W2024128181C2778204606 @default.

• next