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- W2024128265 abstract "In adults, plasma immunoreactive insulin (IRI) response to oral glucose is enhanced by hormones of the enteroinsular axis, provided an increment plasma glucose (ΔPG) of >20 mg/dl occurs. Previously we failed to demonstrate a gastrointestinally (GI) enhanced insulin response in newborns (J. Peds 91:783) infused with glucose at 12 mg/kg.min. However, the PG rarely raised to levels above 100 mg/dl. The purpose of the present study is to reevaluate the IRI response to orogastric (OG) vs intravenously (IV) infused glucose into newborn infants with infusion rates aiming to achieve comparable elevations of PG levels. At age 36-90 hrs, after 4 hr fast, 19 term infants, paired by birthweight categories of appropriate, small or large for gestational age, were infused with glucose at 16 mg/kg.min OG (n=10) or 8 mg/kg.min IV (n=9) for 2 hrs. Serial blood samples for PG and IRI were obtained at 15-30 min intervals for 3 hr. Peak PG were 107±21 mg/dl (M± S.D.) at 30-90 min of IV and 114±17 mg/dl at 60-120 min of OG infusion, while peak IRI were 18±9 μU/ml (IV) vs 42±17 μU/ml (OG)(p<0.001) at 30-90 min and 90-150 min respectively. ΔPG were 50±19 mg/dl in the IV and 52±17 mg/dl in the OG infusion groups. Similar patterns of responses occurred in all weight categories. Concl: 1) The newborn has an enhanced insulin response to GI infused glucose, suggesting the presence of a functional enteroinsular axis, 2) This enhanced insulin response will only occur with an adequate increment of plasma glucose." @default.
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- W2024128265 date "1984-04-01" @default.
- W2024128265 modified "2023-09-26" @default.
- W2024128265 title "FUNCTIONAL ENTERO-INSULAR AXIS IN THE NEWBORN" @default.
- W2024128265 doi "https://doi.org/10.1203/00006450-198404001-00683" @default.
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