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- W2024128554 abstract "A series of guanylhydrazone, amidine, and hydrazone derivatives of 2-phenylimidazo[1,2-a]pyridine have been prepared and evaluated for macrofilarial activity against Acanthocheilonema viteae and Brugia pahangi in jirds. Compounds with 4‘,6-bis-substitution by cyclic guanylhydrazone groups show activity. 4‘,6-Bis-amidines show some activity but are more toxic; 4‘- or 6-monosubstituted compounds are inactive. 2,6-Bis-substituted compounds lacking the phenyl ring are inactive. 4‘,6-Bis-substituted compounds having additional double bonds inserted between the heterocyclic ring and the phenyl ring or between the substituent and the ring system show reduced activity." @default.
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- W2024128554 date "1998-09-18" @default.
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- W2024128554 title "Bis-Cationic Heteroaromatics as Macrofilaricides: Synthesis of Bis-Amidine and Bis<i>-</i>Guanylhydrazone Derivatives of Substituted Imidazo[1,2-<i>a</i>]pyridines" @default.
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- W2024128554 doi "https://doi.org/10.1021/jm9803368" @default.
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