Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024130010> ?p ?o ?g. }
- W2024130010 endingPage "443" @default.
- W2024130010 startingPage "436" @default.
- W2024130010 abstract "The assembly of major histocompatibility complex (MHC) class I molecules with peptides is orchestrated by several assembly factors including the transporter associated with antigen processing (TAP) and tapasin, the endoplasmic reticulum (ER) oxido-reductases ERp57 and protein disulfide isomerase (PDI), the lectin chaperones calnexin and calreticulin, and the ER aminopeptidase (ERAAP). Typically, MHC class I molecules present endogenous antigens to cytotoxic T lymphocytes (CTLs). However, the initiation of CD8+ T-cell responses against many pathogens and tumors also requires the presentation of exogenous antigens by MHC class I molecules. We discuss recent developments relating to interactions and mechanisms of function of the various assembly factors and pathways by which exogenous antigens access MHC class I molecules. The assembly of major histocompatibility complex (MHC) class I molecules with peptides is orchestrated by several assembly factors including the transporter associated with antigen processing (TAP) and tapasin, the endoplasmic reticulum (ER) oxido-reductases ERp57 and protein disulfide isomerase (PDI), the lectin chaperones calnexin and calreticulin, and the ER aminopeptidase (ERAAP). Typically, MHC class I molecules present endogenous antigens to cytotoxic T lymphocytes (CTLs). However, the initiation of CD8+ T-cell responses against many pathogens and tumors also requires the presentation of exogenous antigens by MHC class I molecules. We discuss recent developments relating to interactions and mechanisms of function of the various assembly factors and pathways by which exogenous antigens access MHC class I molecules." @default.
- W2024130010 created "2016-06-24" @default.
- W2024130010 creator A5021992385 @default.
- W2024130010 creator A5034935231 @default.
- W2024130010 creator A5044115470 @default.
- W2024130010 creator A5070666882 @default.
- W2024130010 date "2008-09-01" @default.
- W2024130010 modified "2023-10-16" @default.
- W2024130010 title "MHC class I assembly: out and about" @default.
- W2024130010 cites W1539353750 @default.
- W2024130010 cites W1972899685 @default.
- W2024130010 cites W1977812921 @default.
- W2024130010 cites W1983764349 @default.
- W2024130010 cites W1990702740 @default.
- W2024130010 cites W1994348363 @default.
- W2024130010 cites W1995809457 @default.
- W2024130010 cites W1997131546 @default.
- W2024130010 cites W1997490715 @default.
- W2024130010 cites W2001583092 @default.
- W2024130010 cites W2001609281 @default.
- W2024130010 cites W2001719540 @default.
- W2024130010 cites W2002488282 @default.
- W2024130010 cites W2006690805 @default.
- W2024130010 cites W2009541708 @default.
- W2024130010 cites W2012137725 @default.
- W2024130010 cites W2020746301 @default.
- W2024130010 cites W2022174079 @default.
- W2024130010 cites W2022500038 @default.
- W2024130010 cites W2023967363 @default.
- W2024130010 cites W2030756202 @default.
- W2024130010 cites W2030898714 @default.
- W2024130010 cites W2033605807 @default.
- W2024130010 cites W2041426680 @default.
- W2024130010 cites W2042411369 @default.
- W2024130010 cites W2044050227 @default.
- W2024130010 cites W2046350103 @default.
- W2024130010 cites W2049472329 @default.
- W2024130010 cites W2049882078 @default.
- W2024130010 cites W2058264657 @default.
- W2024130010 cites W2059844048 @default.
- W2024130010 cites W2063445482 @default.
- W2024130010 cites W2065592345 @default.
- W2024130010 cites W2067054083 @default.
- W2024130010 cites W2068051174 @default.
- W2024130010 cites W2068206773 @default.
- W2024130010 cites W2068853695 @default.
- W2024130010 cites W2071084328 @default.
- W2024130010 cites W2072135452 @default.
- W2024130010 cites W2079439306 @default.
- W2024130010 cites W2079722355 @default.
- W2024130010 cites W2080049667 @default.
- W2024130010 cites W2085927355 @default.
- W2024130010 cites W2092974310 @default.
- W2024130010 cites W2093148044 @default.
- W2024130010 cites W2103749584 @default.
- W2024130010 cites W2105515496 @default.
- W2024130010 cites W2109559499 @default.
- W2024130010 cites W2110365405 @default.
- W2024130010 cites W2111935912 @default.
- W2024130010 cites W2119045499 @default.
- W2024130010 cites W2121989605 @default.
- W2024130010 cites W2122865615 @default.
- W2024130010 cites W2123461995 @default.
- W2024130010 cites W2126102313 @default.
- W2024130010 cites W2131000952 @default.
- W2024130010 cites W2131914577 @default.
- W2024130010 cites W2132197730 @default.
- W2024130010 cites W2140814973 @default.
- W2024130010 cites W2141208006 @default.
- W2024130010 cites W2143655005 @default.
- W2024130010 cites W2144249025 @default.
- W2024130010 cites W2146220880 @default.
- W2024130010 cites W2152031508 @default.
- W2024130010 cites W2154792422 @default.
- W2024130010 cites W2158530201 @default.
- W2024130010 cites W2160289525 @default.
- W2024130010 cites W2161529839 @default.
- W2024130010 cites W2161983628 @default.
- W2024130010 cites W2165512405 @default.
- W2024130010 cites W2166630199 @default.
- W2024130010 cites W2167688505 @default.
- W2024130010 cites W2171656250 @default.
- W2024130010 cites W4297691837 @default.
- W2024130010 doi "https://doi.org/10.1016/j.it.2008.06.004" @default.
- W2024130010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2774448" @default.
- W2024130010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18675588" @default.
- W2024130010 hasPublicationYear "2008" @default.
- W2024130010 type Work @default.
- W2024130010 sameAs 2024130010 @default.
- W2024130010 citedByCount "93" @default.
- W2024130010 countsByYear W20241300102012 @default.
- W2024130010 countsByYear W20241300102013 @default.
- W2024130010 countsByYear W20241300102014 @default.
- W2024130010 countsByYear W20241300102015 @default.
- W2024130010 countsByYear W20241300102016 @default.
- W2024130010 countsByYear W20241300102017 @default.
- W2024130010 countsByYear W20241300102018 @default.
- W2024130010 countsByYear W20241300102019 @default.