Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024133387> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2024133387 endingPage "313" @default.
- W2024133387 startingPage "303" @default.
- W2024133387 abstract "A total of 137 microinjections of morphine sulfate in doses of 1.0–50 μg were made into various midbrain sites of 47 rats implanted with chronic indwelling cannulae. Three to six μg of morphine injected in a 0.5 μl volume produced a marked increase in hot plate reaction time when injected into a circumscribed region of the periaqueductal gray matter ventral to the cerebral aqueduct encompassing the dorsal raphe nucleus and bordering tissue. Microinjections of low doses of morphine in other midbrain loci produced less effective antinociceptive activity or no analgesia at all. Higher doses of morphine (10–50 μg) eliminated the pain response to limb pinching, but in addition caused rats to become “hyperreactive,” i.e., to over respond to a variety of stimuli. Death resulted in seven of these hyperreactive rats. Although mild hyperactivity, i.e., spontaneous motor activation, was frequently observed when 3 μg of morphine was microinjected into more lateral midbrain sites, this dose elicited little or no hyperreactivity. The results of these studies are in agreement with those studies that showed identical sites of action for electrical analgesia in the rat. These results suggest morphine and electrical stimulation have similar mechanisms of action in producing analgesia when these active midbrain sites are involved." @default.
- W2024133387 created "2016-06-24" @default.
- W2024133387 creator A5002241878 @default.
- W2024133387 creator A5037324967 @default.
- W2024133387 creator A5070414240 @default.
- W2024133387 date "1974-07-01" @default.
- W2024133387 modified "2023-09-25" @default.
- W2024133387 title "Analgesia and hyperreactivity produced by intracranial microinjections of morphine into the periaqueductal gray matter of the rat" @default.
- W2024133387 cites W1964383984 @default.
- W2024133387 cites W1975670342 @default.
- W2024133387 cites W1981719166 @default.
- W2024133387 cites W1990349022 @default.
- W2024133387 cites W1993321801 @default.
- W2024133387 cites W2010590559 @default.
- W2024133387 cites W2014562627 @default.
- W2024133387 cites W2017391158 @default.
- W2024133387 cites W2023568038 @default.
- W2024133387 cites W2034538296 @default.
- W2024133387 cites W2048712968 @default.
- W2024133387 cites W2053779908 @default.
- W2024133387 cites W2057820904 @default.
- W2024133387 cites W2069008904 @default.
- W2024133387 cites W2070600825 @default.
- W2024133387 cites W2084736340 @default.
- W2024133387 cites W2090371190 @default.
- W2024133387 cites W2092767025 @default.
- W2024133387 cites W2417949885 @default.
- W2024133387 doi "https://doi.org/10.1016/s0091-6773(74)90548-3" @default.
- W2024133387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4411999" @default.
- W2024133387 hasPublicationYear "1974" @default.
- W2024133387 type Work @default.
- W2024133387 sameAs 2024133387 @default.
- W2024133387 citedByCount "156" @default.
- W2024133387 countsByYear W20241333872013 @default.
- W2024133387 countsByYear W20241333872016 @default.
- W2024133387 countsByYear W20241333872018 @default.
- W2024133387 countsByYear W20241333872020 @default.
- W2024133387 crossrefType "journal-article" @default.
- W2024133387 hasAuthorship W2024133387A5002241878 @default.
- W2024133387 hasAuthorship W2024133387A5037324967 @default.
- W2024133387 hasAuthorship W2024133387A5070414240 @default.
- W2024133387 hasConcept C126322002 @default.
- W2024133387 hasConcept C134018914 @default.
- W2024133387 hasConcept C15490471 @default.
- W2024133387 hasConcept C170493617 @default.
- W2024133387 hasConcept C185592680 @default.
- W2024133387 hasConcept C24998067 @default.
- W2024133387 hasConcept C2777389121 @default.
- W2024133387 hasConcept C2781069035 @default.
- W2024133387 hasConcept C2909233451 @default.
- W2024133387 hasConcept C42219234 @default.
- W2024133387 hasConcept C529278444 @default.
- W2024133387 hasConcept C552161191 @default.
- W2024133387 hasConcept C62525196 @default.
- W2024133387 hasConcept C71924100 @default.
- W2024133387 hasConceptScore W2024133387C126322002 @default.
- W2024133387 hasConceptScore W2024133387C134018914 @default.
- W2024133387 hasConceptScore W2024133387C15490471 @default.
- W2024133387 hasConceptScore W2024133387C170493617 @default.
- W2024133387 hasConceptScore W2024133387C185592680 @default.
- W2024133387 hasConceptScore W2024133387C24998067 @default.
- W2024133387 hasConceptScore W2024133387C2777389121 @default.
- W2024133387 hasConceptScore W2024133387C2781069035 @default.
- W2024133387 hasConceptScore W2024133387C2909233451 @default.
- W2024133387 hasConceptScore W2024133387C42219234 @default.
- W2024133387 hasConceptScore W2024133387C529278444 @default.
- W2024133387 hasConceptScore W2024133387C552161191 @default.
- W2024133387 hasConceptScore W2024133387C62525196 @default.
- W2024133387 hasConceptScore W2024133387C71924100 @default.
- W2024133387 hasIssue "3" @default.
- W2024133387 hasLocation W20241333871 @default.
- W2024133387 hasLocation W20241333872 @default.
- W2024133387 hasOpenAccess W2024133387 @default.
- W2024133387 hasPrimaryLocation W20241333871 @default.
- W2024133387 hasRelatedWork W1978319366 @default.
- W2024133387 hasRelatedWork W1987900987 @default.
- W2024133387 hasRelatedWork W1989644542 @default.
- W2024133387 hasRelatedWork W2005022725 @default.
- W2024133387 hasRelatedWork W2024133387 @default.
- W2024133387 hasRelatedWork W2055608327 @default.
- W2024133387 hasRelatedWork W2076474750 @default.
- W2024133387 hasRelatedWork W2422394546 @default.
- W2024133387 hasRelatedWork W2423770365 @default.
- W2024133387 hasRelatedWork W2777909583 @default.
- W2024133387 hasVolume "11" @default.
- W2024133387 isParatext "false" @default.
- W2024133387 isRetracted "false" @default.
- W2024133387 magId "2024133387" @default.
- W2024133387 workType "article" @default.