FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024133603> ?p ?o ?g. }

• W2024133603 endingPage "33" @default.
• W2024133603 startingPage "23" @default.
• W2024133603 abstract "Movement of zinc ions across cellular membranes is achieved mainly by two families of zinc transport genes encoding multi-transmembrane domain proteins. Members of the Zip family generally transport zinc into the cytosol, either from outside the cell or from the lumen of subcellular organelles such as the endoplasmic reticulum, Golgi, endosomes or storage vacuoles. ZnT proteins move zinc in the opposite direction, resulting in efflux from the cell or uptake into organelles. Zinc homeostasis at both the cellular and systemic level is achieved by the coordinated action of numerous Zip and ZnT proteins, twenty-four in mammals and seventeen in the vinegar fly Drosophila melanogaster. Previously, we have identified a zinc toxicity phenotype in the Drosophila eye, caused by targeted over expression of dZip42C.1 (dZip1) combined with knockdown of dZnT63C (dZnT1). In general, this phenotype was rescued by increased zinc efflux or decreased uptake and was exacerbated by decreased efflux or increased uptake. Now we have identified three additional zinc dyshomeostasis phenotypes caused by over expression of dZnT86D, dZnT86DeGFP and dZip71BFLAG. Genetic and dietary manipulation experiments showed that these three phenotypes all differ both from each other and from our original zinc toxicity phenotype. Based on these data and the approximate subcellular localization of each zinc transport protein, we propose that each phenotype represents a different redistribution of zinc within these cells, resulting in a Golgi zinc toxicity, a Golgi zinc deficiency and a combined Golgi/other organelle zinc toxicity respectively. We are able to group the remaining Drosophila Zip and ZnT genes into several functional categories based on their interaction with the three novel zinc dyshomeostasis phenotypes, allowing the role of each zinc transport protein to be defined in greater detail. This research highlights the differential effects that redistribution of zinc can have within a particular tissue and identifies the Golgi as being particularly sensitive to both excess and insufficient zinc." @default.
• W2024133603 created "2016-06-24" @default.
• W2024133603 creator A5007013271 @default.
• W2024133603 creator A5032263351 @default.
• W2024133603 creator A5038178410 @default.
• W2024133603 creator A5056994767 @default.
• W2024133603 creator A5090717032 @default.
• W2024133603 date "2015-03-01" @default.
• W2024133603 modified "2023-09-25" @default.
• W2024133603 title "Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila" @default.
• W2024133603 cites W1969601086 @default.
• W2024133603 cites W1979178201 @default.
• W2024133603 cites W1980139245 @default.
• W2024133603 cites W1993044829 @default.
• W2024133603 cites W2006272730 @default.
• W2024133603 cites W2017469965 @default.
• W2024133603 cites W2017589639 @default.
• W2024133603 cites W2025556080 @default.
• W2024133603 cites W2032153850 @default.
• W2024133603 cites W2069451604 @default.
• W2024133603 cites W2082725373 @default.
• W2024133603 cites W2091760058 @default.
• W2024133603 cites W2092676399 @default.
• W2024133603 cites W2095882212 @default.
• W2024133603 cites W2097969090 @default.
• W2024133603 cites W2103270725 @default.
• W2024133603 cites W2124272755 @default.
• W2024133603 cites W2147187321 @default.
• W2024133603 cites W2161175302 @default.
• W2024133603 cites W2333904106 @default.
• W2024133603 doi "https://doi.org/10.1016/j.biocel.2014.12.017" @default.
• W2024133603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25562517" @default.
• W2024133603 hasPublicationYear "2015" @default.
• W2024133603 type Work @default.
• W2024133603 sameAs 2024133603 @default.
• W2024133603 citedByCount "23" @default.
• W2024133603 countsByYear W20241336032015 @default.
• W2024133603 countsByYear W20241336032016 @default.
• W2024133603 countsByYear W20241336032017 @default.
• W2024133603 countsByYear W20241336032018 @default.
• W2024133603 countsByYear W20241336032019 @default.
• W2024133603 countsByYear W20241336032020 @default.
• W2024133603 countsByYear W20241336032021 @default.
• W2024133603 countsByYear W20241336032022 @default.
• W2024133603 countsByYear W20241336032023 @default.
• W2024133603 crossrefType "journal-article" @default.
• W2024133603 hasAuthorship W2024133603A5007013271 @default.
• W2024133603 hasAuthorship W2024133603A5032263351 @default.
• W2024133603 hasAuthorship W2024133603A5038178410 @default.
• W2024133603 hasAuthorship W2024133603A5056994767 @default.
• W2024133603 hasAuthorship W2024133603A5090717032 @default.
• W2024133603 hasConcept C102568950 @default.
• W2024133603 hasConcept C102747710 @default.
• W2024133603 hasConcept C104317684 @default.
• W2024133603 hasConcept C119062480 @default.
• W2024133603 hasConcept C127716648 @default.
• W2024133603 hasConcept C158617107 @default.
• W2024133603 hasConcept C168240541 @default.
• W2024133603 hasConcept C173396325 @default.
• W2024133603 hasConcept C178790620 @default.
• W2024133603 hasConcept C185592680 @default.
• W2024133603 hasConcept C190062978 @default.
• W2024133603 hasConcept C200082930 @default.
• W2024133603 hasConcept C2778290051 @default.
• W2024133603 hasConcept C2780104201 @default.
• W2024133603 hasConcept C535196362 @default.
• W2024133603 hasConcept C55493867 @default.
• W2024133603 hasConcept C57581600 @default.
• W2024133603 hasConcept C79879829 @default.
• W2024133603 hasConcept C86803240 @default.
• W2024133603 hasConcept C95444343 @default.
• W2024133603 hasConceptScore W2024133603C102568950 @default.
• W2024133603 hasConceptScore W2024133603C102747710 @default.
• W2024133603 hasConceptScore W2024133603C104317684 @default.
• W2024133603 hasConceptScore W2024133603C119062480 @default.
• W2024133603 hasConceptScore W2024133603C127716648 @default.
• W2024133603 hasConceptScore W2024133603C158617107 @default.
• W2024133603 hasConceptScore W2024133603C168240541 @default.
• W2024133603 hasConceptScore W2024133603C173396325 @default.
• W2024133603 hasConceptScore W2024133603C178790620 @default.
• W2024133603 hasConceptScore W2024133603C185592680 @default.
• W2024133603 hasConceptScore W2024133603C190062978 @default.
• W2024133603 hasConceptScore W2024133603C200082930 @default.
• W2024133603 hasConceptScore W2024133603C2778290051 @default.
• W2024133603 hasConceptScore W2024133603C2780104201 @default.
• W2024133603 hasConceptScore W2024133603C535196362 @default.
• W2024133603 hasConceptScore W2024133603C55493867 @default.
• W2024133603 hasConceptScore W2024133603C57581600 @default.
• W2024133603 hasConceptScore W2024133603C79879829 @default.
• W2024133603 hasConceptScore W2024133603C86803240 @default.
• W2024133603 hasConceptScore W2024133603C95444343 @default.
• W2024133603 hasLocation W20241336031 @default.
• W2024133603 hasLocation W20241336032 @default.
• W2024133603 hasOpenAccess W2024133603 @default.
• W2024133603 hasPrimaryLocation W20241336031 @default.
• W2024133603 hasRelatedWork W1033355208 @default.
• W2024133603 hasRelatedWork W1968774879 @default.
• W2024133603 hasRelatedWork W1979365145 @default.

• next