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- W2024135052 abstract "Objective: Limited information is available regarding the differences in clinical characteristics and survival of patients with hypoalbuminemia, compared to patients with normal levels of serum albumin, in the general internal medicine ward population. Our aim was two-fold: 1) to compare the clinical characteristics and long-term survival between patients admitted to an internal medicine ward with and without hypoalbuminemia; 2) to investigate the prognostic significance of dynamic changes of serum albumin during hospitalization. Methods: Demographic, clinical and laboratory data were collected for 276 patients admitted to an internal medicine ward for a variety of acute disorders. Following discharge, all-cause mortality was recorded. These data were compared between patient groups, divided according to their levels of albumin: hypoalbuminemia or normoalbuminemia (serum albumin <34 g/l and ≥34 g/l, respectively), on admission and discharge. Results: Hypoalbuminemia on admission and on discharge was found in 46% and 54% of patients, respectively. Anemia, renal dysfunction, malignant disease, hypocholesterolemia and lymphopenia were more prevalent in patients with hypoalbuminemia, compared to those with normoalbuminemia (p ≤ 0.03). Furthermore, in patients with hypoalbuminemia the mean values of C-reactive protein (p < 0.001) and neutrophil count (p = 0.006) were higher, and their hospital stay was prolonged (p = 0.002). During a median follow-up period of 23 months, 107 of 276 patients died. Mortality was significantly higher (p < 0.001) in patients with hypoalbuminemia than normoalbuminemia on admission (52.0% vs. 27.5%) and on discharge (53.7% vs. 21.2%), including those admitted with normoalbuminemia but discharged with hypoalbuminemia (43.6%). Survival rate was higher for patients admitted with hypoalbuminema and discharged with normoalbuminemia, compared to those remaining with hypoalbuminemia (82.4% vs. 42.8%, p = 0.004). The level of albumin on discharge (each 10 g/l decrement) was the most powerful predictor of shortened survival (relative risk 2.79, 95% confidence interval 2.04–3.70). Conclusions: Hypoalbuminemia commonly presents in internal medicine wards. Clinical and laboratory characteristics are more severe among patients with hypoalbuminemia than among those with normoalbuminemia. Hypoalbuminemia on admission, as well as persistence or development of hypoalbuminemia throughout hospitalization, are associated with poor prognosis. Effective treatment of patients with hypoalbuminemia, aimed to increase or maintain serum albumin levels, may improve survival." @default.
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- W2024135052 date "2013-10-01" @default.
- W2024135052 modified "2023-09-26" @default.
- W2024135052 title "Hypoalbuminemia at an internal medicine ward: Clinical features and prognostic implications" @default.
- W2024135052 doi "https://doi.org/10.1016/j.ejim.2013.08.409" @default.
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