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- W2024136345 abstract "TRPV1 measured in lipid bilayers The TRPV1 ion channel is a member of the transient receptor potential ion channel family which is known to respond to temperature, voltage and certain chemicals such as capsaicin. We have engineered a HEK cell line expressing FLAG-tagged TRPV1. Cellular measurements of expressed TRPV1 with capsaicin resulted in dose dependent activation with an IC50 of approximately 10 nM. Reconstitution of purified TRPV1 and membrane preparations containing TRPV1 in lipid bilayers resulted in conductance measurements of single and multiple channels. We present bilayer measurements of TRPV1 conductance as a function of voltage, temperature, and presence of agonist and antagonist chemicals." @default.
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- W2024136345 date "2014-01-01" @default.
- W2024136345 modified "2023-09-27" @default.
- W2024136345 title "TRPV1 Measured in Lipid Bilayers" @default.
- W2024136345 doi "https://doi.org/10.1016/j.bpj.2013.11.4166" @default.
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