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• W2024136757 startingPage "119" @default.
• W2024136757 abstract "Rainbow trout, as well as many other species of fish, demonstrate the ability to survive starvation for long periods of time. During starvation, growth rate is decreased and muscle exhibits signs of wasting. However, upon resumption of feeding, accelerated growth is often observed. Alterations in muscle metabolism occur during feed restriction and refeeding, although the ways in which these alterations affect the molecular pathways that control muscle growth have not been fully determined. To analyze changes in muscle metabolism and growth during starvation and refeeding, real-time PCR was used to test the expression of six metabolic-related genes and eight muscle-specific genes in rainbow trout white muscle prior to and after 30 days of starvation, and after 4 and 14 days of refeeding. The six metabolic-related genes chosen are indicative of specific metabolic pathways: glycolysis, glycogenesis, gluconeogenesis, the pentose phosphate pathway, and fatty acid formation. The eight muscle specific genes chosen are key components in muscle growth and structural integrity, i.e., MRFs, MEFs, myostatins, and myosin. Alterations in expression of the tested metabolic-related genes and muscle-specific genes suggest that during both starvation and refeeding, changes in specific metabolic pathways initiate shifts in muscle that result mainly in the modification of myotube hypertrophy. The expression levels of many of the metabolic-related genes were altered during the refeeding period compared to those observed before the starvation period began. However, the accelerated growth often observed during refeeding is likely driven by changes in normal muscle metabolism, and the altered expression observed here may be a demonstration of those changes." @default.
• W2024136757 created "2016-06-24" @default.
• W2024136757 creator A5040063941 @default.
• W2024136757 creator A5058585666 @default.
• W2024136757 date "2006-05-01" @default.
• W2024136757 modified "2023-09-25" @default.
• W2024136757 title "Alterations in expression of genes associated with muscle metabolism and growth during nutritional restriction and refeeding in rainbow trout" @default.
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• W2024136757 doi "https://doi.org/10.1016/j.cbpb.2006.02.001" @default.
• W2024136757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16545592" @default.
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