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• W2024137212 startingPage "617" @default.
• W2024137212 abstract "Membrane type-1 matrix metalloproteinase (MT1-MMP) is a proinvasive protease that regulates various cellular functions as evidenced by myriad defects in different types of cells and tissues in MT1-MMP-deficient (MT1−/–) mice. Here we demonstrate that MT1−/– mice exhibit fewer infiltrating macrophages into sites of inflammation. MT1−/–macrophages exhibited a reduced ability to invade reconstituted basement membrane (Matrigel) and invasion by wild type (WT) macrophages was inhibited by a synthetic MMP inhibitor (BB94) to a level similar to that of MT1−/– cells. The rate of migration of MT1−/– macrophages was also low compared to that of the WT cells and re-expression of MT1-MMP in MT1−/– macrophages reconstituted their migratory activity. Unexpectedly, however, BB94 did not inhibit the migration of WT macrophages. The migration-boosting activity of MT1-MMP is retained in a mutant that lacks most of the extracellular portion including the catalytic and hemopexin-like domains. In contrast, deletion of the cytoplasmic (CP) tail abolished the activity completely. Thus, we have demonstrated that MT1-MMP regulates macrophages via its invasion-promoting protease activity as well as its CP-dependent non-proteolytic activity to boost cell migration." @default.
• W2024137212 created "2016-06-24" @default.
• W2024137212 creator A5008902984 @default.
• W2024137212 creator A5022311927 @default.
• W2024137212 date "2009-05-01" @default.
• W2024137212 modified "2023-10-02" @default.
• W2024137212 title "Cytoplasmic tail of MT1-MMP regulates macrophage motility independently from its protease activity" @default.
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• W2024137212 doi "https://doi.org/10.1111/j.1365-2443.2009.01293.x" @default.
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