FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024138863> ?p ?o ?g. }

• W2024138863 endingPage "e112619" @default.
• W2024138863 startingPage "e112619" @default.
• W2024138863 abstract "Acute Myeloid Leukemia (AML) is an aggressive malignancy which leads to marrow failure, and ultimately death. There is a desperate need for new therapeutics for these patients. Ribonucleotide reductase (RR) is the rate limiting enzyme in DNA synthesis. Didox (3,4-Dihydroxybenzohydroxamic acid) is a novel RR inhibitor noted to be more potent than hydroxyurea. In this report we detail the activity and toxicity of Didox in preclinical models of AML. RR was present in all AML cell lines and primary patient samples tested. Didox was active against all human and murine AML lines tested with IC50 values in the low micromolar range (mean IC50 37 µM [range 25.89-52.70 µM]). It was active against primary patient samples at concentrations that did not affect normal hematopoietic stem cells (HSCs). Didox exposure resulted in DNA damage and p53 induction culminating in apoptosis. In syngeneic, therapy-resistant AML models, single agent Didox treatment resulted in a significant reduction in leukemia burden and a survival benefit. Didox was well tolerated, as marrow from treated animals was morphologically indistinguishable from controls. Didox exposure at levels that impaired leukemia growth did not inhibit normal HSC engraftment. In summary, Didox was well tolerated and effective against preclinical models of AML." @default.
• W2024138863 created "2016-06-24" @default.
• W2024138863 creator A5009565869 @default.
• W2024138863 creator A5049848146 @default.
• W2024138863 creator A5072334880 @default.
• W2024138863 creator A5090348719 @default.
• W2024138863 date "2014-11-17" @default.
• W2024138863 modified "2023-09-27" @default.
• W2024138863 title "The Efficacy of the Ribonucleotide Reductase Inhibitor Didox in Preclinical Models of AML" @default.
• W2024138863 cites W140845169 @default.
• W2024138863 cites W1596026758 @default.
• W2024138863 cites W1648486104 @default.
• W2024138863 cites W176252834 @default.
• W2024138863 cites W1860795225 @default.
• W2024138863 cites W1968291566 @default.
• W2024138863 cites W1986702985 @default.
• W2024138863 cites W1995630317 @default.
• W2024138863 cites W1998475390 @default.
• W2024138863 cites W2002092626 @default.
• W2024138863 cites W2005081323 @default.
• W2024138863 cites W2007816122 @default.
• W2024138863 cites W2010898909 @default.
• W2024138863 cites W2031777014 @default.
• W2024138863 cites W2032706980 @default.
• W2024138863 cites W2043402587 @default.
• W2024138863 cites W2055319158 @default.
• W2024138863 cites W2063607020 @default.
• W2024138863 cites W2065464763 @default.
• W2024138863 cites W2068140004 @default.
• W2024138863 cites W2068556430 @default.
• W2024138863 cites W2074156234 @default.
• W2024138863 cites W2081330846 @default.
• W2024138863 cites W2095526757 @default.
• W2024138863 cites W2100191669 @default.
• W2024138863 cites W2116858301 @default.
• W2024138863 cites W2122659245 @default.
• W2024138863 cites W2136463978 @default.
• W2024138863 cites W2140531885 @default.
• W2024138863 cites W2157305385 @default.
• W2024138863 cites W2158380484 @default.
• W2024138863 cites W2159738043 @default.
• W2024138863 cites W2167853936 @default.
• W2024138863 cites W2170846829 @default.
• W2024138863 cites W2184190880 @default.
• W2024138863 cites W56955416 @default.
• W2024138863 doi "https://doi.org/10.1371/journal.pone.0112619" @default.
• W2024138863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4234372" @default.
• W2024138863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25402485" @default.
• W2024138863 hasPublicationYear "2014" @default.
• W2024138863 type Work @default.
• W2024138863 sameAs 2024138863 @default.
• W2024138863 citedByCount "8" @default.
• W2024138863 countsByYear W20241388632015 @default.
• W2024138863 countsByYear W20241388632016 @default.
• W2024138863 countsByYear W20241388632017 @default.
• W2024138863 countsByYear W20241388632019 @default.
• W2024138863 countsByYear W20241388632020 @default.
• W2024138863 crossrefType "journal-article" @default.
• W2024138863 hasAuthorship W2024138863A5009565869 @default.
• W2024138863 hasAuthorship W2024138863A5049848146 @default.
• W2024138863 hasAuthorship W2024138863A5072334880 @default.
• W2024138863 hasAuthorship W2024138863A5090348719 @default.
• W2024138863 hasBestOaLocation W20241388631 @default.
• W2024138863 hasConcept C104292427 @default.
• W2024138863 hasConcept C104317684 @default.
• W2024138863 hasConcept C109159458 @default.
• W2024138863 hasConcept C203014093 @default.
• W2024138863 hasConcept C2778041864 @default.
• W2024138863 hasConcept C2778461978 @default.
• W2024138863 hasConcept C2778729363 @default.
• W2024138863 hasConcept C28328180 @default.
• W2024138863 hasConcept C4710235 @default.
• W2024138863 hasConcept C502942594 @default.
• W2024138863 hasConcept C54355233 @default.
• W2024138863 hasConcept C55493867 @default.
• W2024138863 hasConcept C86803240 @default.
• W2024138863 hasConcept C98274493 @default.
• W2024138863 hasConceptScore W2024138863C104292427 @default.
• W2024138863 hasConceptScore W2024138863C104317684 @default.
• W2024138863 hasConceptScore W2024138863C109159458 @default.
• W2024138863 hasConceptScore W2024138863C203014093 @default.
• W2024138863 hasConceptScore W2024138863C2778041864 @default.
• W2024138863 hasConceptScore W2024138863C2778461978 @default.
• W2024138863 hasConceptScore W2024138863C2778729363 @default.
• W2024138863 hasConceptScore W2024138863C28328180 @default.
• W2024138863 hasConceptScore W2024138863C4710235 @default.
• W2024138863 hasConceptScore W2024138863C502942594 @default.
• W2024138863 hasConceptScore W2024138863C54355233 @default.
• W2024138863 hasConceptScore W2024138863C55493867 @default.
• W2024138863 hasConceptScore W2024138863C86803240 @default.
• W2024138863 hasConceptScore W2024138863C98274493 @default.
• W2024138863 hasIssue "11" @default.
• W2024138863 hasLocation W20241388631 @default.
• W2024138863 hasLocation W20241388632 @default.
• W2024138863 hasLocation W20241388633 @default.
• W2024138863 hasLocation W20241388634 @default.
• W2024138863 hasLocation W20241388635 @default.
• W2024138863 hasOpenAccess W2024138863 @default.

• next