Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024141615> ?p ?o ?g. }
- W2024141615 endingPage "273" @default.
- W2024141615 startingPage "260" @default.
- W2024141615 abstract "Exquisite control of cholesterol synthesis is crucial for maintaining homeostasis of this vital yet potentially toxic lipid. Squalene monooxygenase (SM) catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure. Using model cell systems, we found that cholesterol caused the accumulation of the substrate squalene, suggesting that SM may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, considered as rate limiting). Cholesterol accelerated the proteasomal degradation of SM which required the N-terminal domain, partially conserved in vertebrates but not in lower organisms. Unlike HMGR, SM degradation is not mediated by Insig, 24,25-dihydrolanosterol, or side-chain oxysterols, but rather by cholesterol itself. Importantly, SM's N-terminal domain conferred cholesterol-regulated turnover on heterologous fusion proteins. Furthermore, proteasomal inhibition almost totally eliminated squalene accumulation, highlighting the importance of this degradation mechanism for the control of SM and suggesting this as a possible control point in cholesterol synthesis." @default.
- W2024141615 created "2016-06-24" @default.
- W2024141615 creator A5020607137 @default.
- W2024141615 creator A5054670005 @default.
- W2024141615 creator A5084345521 @default.
- W2024141615 creator A5087402061 @default.
- W2024141615 date "2011-03-01" @default.
- W2024141615 modified "2023-10-13" @default.
- W2024141615 title "Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase" @default.
- W2024141615 cites W13351788 @default.
- W2024141615 cites W1562811405 @default.
- W2024141615 cites W1606948338 @default.
- W2024141615 cites W1678687940 @default.
- W2024141615 cites W1860242155 @default.
- W2024141615 cites W1905286773 @default.
- W2024141615 cites W1968067153 @default.
- W2024141615 cites W1972316642 @default.
- W2024141615 cites W2006050842 @default.
- W2024141615 cites W2006415446 @default.
- W2024141615 cites W2007422965 @default.
- W2024141615 cites W2016441481 @default.
- W2024141615 cites W2022110114 @default.
- W2024141615 cites W2026081876 @default.
- W2024141615 cites W2027486144 @default.
- W2024141615 cites W2034597340 @default.
- W2024141615 cites W2038955973 @default.
- W2024141615 cites W2046573621 @default.
- W2024141615 cites W2050412627 @default.
- W2024141615 cites W2061523619 @default.
- W2024141615 cites W2064875837 @default.
- W2024141615 cites W2071251525 @default.
- W2024141615 cites W2072231367 @default.
- W2024141615 cites W2074472939 @default.
- W2024141615 cites W2082781136 @default.
- W2024141615 cites W2097632838 @default.
- W2024141615 cites W2097866765 @default.
- W2024141615 cites W2113574245 @default.
- W2024141615 cites W2115420718 @default.
- W2024141615 cites W2126842666 @default.
- W2024141615 cites W2130716475 @default.
- W2024141615 cites W2138486337 @default.
- W2024141615 cites W2147506734 @default.
- W2024141615 cites W2151572115 @default.
- W2024141615 cites W2152137138 @default.
- W2024141615 cites W2158157260 @default.
- W2024141615 cites W2171705910 @default.
- W2024141615 cites W2174559065 @default.
- W2024141615 cites W2183105529 @default.
- W2024141615 cites W2439249793 @default.
- W2024141615 doi "https://doi.org/10.1016/j.cmet.2011.01.015" @default.
- W2024141615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21356516" @default.
- W2024141615 hasPublicationYear "2011" @default.
- W2024141615 type Work @default.
- W2024141615 sameAs 2024141615 @default.
- W2024141615 citedByCount "238" @default.
- W2024141615 countsByYear W20241416152012 @default.
- W2024141615 countsByYear W20241416152013 @default.
- W2024141615 countsByYear W20241416152014 @default.
- W2024141615 countsByYear W20241416152015 @default.
- W2024141615 countsByYear W20241416152016 @default.
- W2024141615 countsByYear W20241416152017 @default.
- W2024141615 countsByYear W20241416152018 @default.
- W2024141615 countsByYear W20241416152019 @default.
- W2024141615 countsByYear W20241416152020 @default.
- W2024141615 countsByYear W20241416152021 @default.
- W2024141615 countsByYear W20241416152022 @default.
- W2024141615 countsByYear W20241416152023 @default.
- W2024141615 crossrefType "journal-article" @default.
- W2024141615 hasAuthorship W2024141615A5020607137 @default.
- W2024141615 hasAuthorship W2024141615A5054670005 @default.
- W2024141615 hasAuthorship W2024141615A5084345521 @default.
- W2024141615 hasAuthorship W2024141615A5087402061 @default.
- W2024141615 hasBestOaLocation W20241416151 @default.
- W2024141615 hasConcept C104788683 @default.
- W2024141615 hasConcept C104950815 @default.
- W2024141615 hasConcept C134651460 @default.
- W2024141615 hasConcept C181199279 @default.
- W2024141615 hasConcept C185592680 @default.
- W2024141615 hasConcept C2776703722 @default.
- W2024141615 hasConcept C2777320049 @default.
- W2024141615 hasConcept C2778163477 @default.
- W2024141615 hasConcept C2779123261 @default.
- W2024141615 hasConcept C2779982574 @default.
- W2024141615 hasConcept C553450214 @default.
- W2024141615 hasConcept C55493867 @default.
- W2024141615 hasConcept C85411794 @default.
- W2024141615 hasConcept C86803240 @default.
- W2024141615 hasConceptScore W2024141615C104788683 @default.
- W2024141615 hasConceptScore W2024141615C104950815 @default.
- W2024141615 hasConceptScore W2024141615C134651460 @default.
- W2024141615 hasConceptScore W2024141615C181199279 @default.
- W2024141615 hasConceptScore W2024141615C185592680 @default.
- W2024141615 hasConceptScore W2024141615C2776703722 @default.
- W2024141615 hasConceptScore W2024141615C2777320049 @default.
- W2024141615 hasConceptScore W2024141615C2778163477 @default.
- W2024141615 hasConceptScore W2024141615C2779123261 @default.
- W2024141615 hasConceptScore W2024141615C2779982574 @default.
- W2024141615 hasConceptScore W2024141615C553450214 @default.