FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024143047> ?p ?o ?g. }

• W2024143047 endingPage "62" @default.
• W2024143047 startingPage "57" @default.
• W2024143047 abstract "We characterized truncations of the human vasopressin V2 receptor to determine the role of the intracellular C‐terminus (comprising about 44 amino acids) in receptor function and cell surface expression. In contrast to the wild‐type receptor, the naturally occurring mutant R337X failed to confer specific [ 3 H]AVP binding to transfected cells. In addition, no vasopressin‐sensitive adenylyl cyclase was detectable in membrane preparations of these cells. Laser scanning microscopy revealed that c‐ myc epitope‐ or green fluorescent protein‐tagged R337X mutant receptors were retained within the endoplasmic reticulum. Increasing the number of C‐terminal residues (truncations after codons 348, 354 and 356) restored G protein coupling, but revealed a length‐dependent reduction of cell surface expression. Replacement of positively charged residues within the C‐terminus by glutamine residues also decreased cell surface expression. A chimeric V2 receptor with the C‐terminus replaced by that of the β 2 ‐adrenergic receptor did not bind [ 3 H]AVP and was retained within the cell. These data suggest that residues in the N‐terminal part of the C‐terminus are necessary for correct folding and that C‐terminal residues are important for efficient cell surface expression." @default.
• W2024143047 created "2016-06-24" @default.
• W2024143047 creator A5020668359 @default.
• W2024143047 creator A5027679081 @default.
• W2024143047 creator A5029193708 @default.
• W2024143047 creator A5051087138 @default.
• W2024143047 creator A5059673448 @default.
• W2024143047 date "1998-03-06" @default.
• W2024143047 modified "2023-10-12" @default.
• W2024143047 title "Folding and cell surface expression of the vasopressin V2 receptor: requirement of the intracellular C‐terminus" @default.
• W2024143047 cites W1445935732 @default.
• W2024143047 cites W1491183049 @default.
• W2024143047 cites W1605056014 @default.
• W2024143047 cites W1963912362 @default.
• W2024143047 cites W1984096535 @default.
• W2024143047 cites W2000077668 @default.
• W2024143047 cites W2023781876 @default.
• W2024143047 cites W2025494172 @default.
• W2024143047 cites W2035235617 @default.
• W2024143047 cites W2043393099 @default.
• W2024143047 cites W2072353408 @default.
• W2024143047 cites W2102863331 @default.
• W2024143047 cites W2122782169 @default.
• W2024143047 cites W2189000105 @default.
• W2024143047 cites W2213314266 @default.
• W2024143047 cites W2264655299 @default.
• W2024143047 cites W25763026 @default.
• W2024143047 cites W61532108 @default.
• W2024143047 doi "https://doi.org/10.1016/s0014-5793(98)00140-9" @default.
• W2024143047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9537515" @default.
• W2024143047 hasPublicationYear "1998" @default.
• W2024143047 type Work @default.
• W2024143047 sameAs 2024143047 @default.
• W2024143047 citedByCount "68" @default.
• W2024143047 countsByYear W20241430472012 @default.
• W2024143047 countsByYear W20241430472014 @default.
• W2024143047 countsByYear W20241430472015 @default.
• W2024143047 countsByYear W20241430472018 @default.
• W2024143047 countsByYear W20241430472019 @default.
• W2024143047 crossrefType "journal-article" @default.
• W2024143047 hasAuthorship W2024143047A5020668359 @default.
• W2024143047 hasAuthorship W2024143047A5027679081 @default.
• W2024143047 hasAuthorship W2024143047A5029193708 @default.
• W2024143047 hasAuthorship W2024143047A5051087138 @default.
• W2024143047 hasAuthorship W2024143047A5059673448 @default.
• W2024143047 hasBestOaLocation W20241430471 @default.
• W2024143047 hasConcept C104317684 @default.
• W2024143047 hasConcept C123894998 @default.
• W2024143047 hasConcept C14053116 @default.
• W2024143047 hasConcept C143065580 @default.
• W2024143047 hasConcept C1491633281 @default.
• W2024143047 hasConcept C153911025 @default.
• W2024143047 hasConcept C158617107 @default.
• W2024143047 hasConcept C167625842 @default.
• W2024143047 hasConcept C170493617 @default.
• W2024143047 hasConcept C17971392 @default.
• W2024143047 hasConcept C197462201 @default.
• W2024143047 hasConcept C20352681 @default.
• W2024143047 hasConcept C2776885963 @default.
• W2024143047 hasConcept C2778106830 @default.
• W2024143047 hasConcept C2779178603 @default.
• W2024143047 hasConcept C40767141 @default.
• W2024143047 hasConcept C515207424 @default.
• W2024143047 hasConcept C54009773 @default.
• W2024143047 hasConcept C55493867 @default.
• W2024143047 hasConcept C57711820 @default.
• W2024143047 hasConcept C79879829 @default.
• W2024143047 hasConcept C86803240 @default.
• W2024143047 hasConcept C95444343 @default.
• W2024143047 hasConceptScore W2024143047C104317684 @default.
• W2024143047 hasConceptScore W2024143047C123894998 @default.
• W2024143047 hasConceptScore W2024143047C14053116 @default.
• W2024143047 hasConceptScore W2024143047C143065580 @default.
• W2024143047 hasConceptScore W2024143047C1491633281 @default.
• W2024143047 hasConceptScore W2024143047C153911025 @default.
• W2024143047 hasConceptScore W2024143047C158617107 @default.
• W2024143047 hasConceptScore W2024143047C167625842 @default.
• W2024143047 hasConceptScore W2024143047C170493617 @default.
• W2024143047 hasConceptScore W2024143047C17971392 @default.
• W2024143047 hasConceptScore W2024143047C197462201 @default.
• W2024143047 hasConceptScore W2024143047C20352681 @default.
• W2024143047 hasConceptScore W2024143047C2776885963 @default.
• W2024143047 hasConceptScore W2024143047C2778106830 @default.
• W2024143047 hasConceptScore W2024143047C2779178603 @default.
• W2024143047 hasConceptScore W2024143047C40767141 @default.
• W2024143047 hasConceptScore W2024143047C515207424 @default.
• W2024143047 hasConceptScore W2024143047C54009773 @default.
• W2024143047 hasConceptScore W2024143047C55493867 @default.
• W2024143047 hasConceptScore W2024143047C57711820 @default.
• W2024143047 hasConceptScore W2024143047C79879829 @default.
• W2024143047 hasConceptScore W2024143047C86803240 @default.
• W2024143047 hasConceptScore W2024143047C95444343 @default.
• W2024143047 hasIssue "1-2" @default.
• W2024143047 hasLocation W20241430471 @default.
• W2024143047 hasLocation W20241430472 @default.
• W2024143047 hasOpenAccess W2024143047 @default.
• W2024143047 hasPrimaryLocation W20241430471 @default.
• W2024143047 hasRelatedWork W1991233227 @default.

• next