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- W2024144069 abstract "Using indirect immunofluorescence we have examined the distribution of the cell surface and extracellular matrix glycoprotein fibronectin at the epithelial-mesenchymal interface and in the mesenchyme of developing chick and duck wing buds. At all stages examined, in both species, staining for fibronectin is greatly enhanced in the basement membrane subjacent to the apical ectodermal ridge (AER), a site of inductive tissue interaction, relative to the epithelial basement membranes in the noninductive dorsal and ventral limb epithelial-mesenchymal interfaces. In stage 23, 25, and 28 chick limb buds, staining for fibronectin is uniform in the least mature distal mesenchyme, retained between more proximal cells undergoing precartilage condensation and lost in those regions undergoing myogenesis, and persistent in all but the most mature cartilage present at the latest stage examined. These results are consistent with a role for fibronectin in AER-induced limb outgrowth, and with a transient role for the glycoprotein in the formation of the skeletal pattern of the limb." @default.
- W2024144069 created "2016-06-24" @default.
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- W2024144069 date "1982-03-01" @default.
- W2024144069 modified "2023-10-17" @default.
- W2024144069 title "Nonuniform distribution of fibronectin during avian limb development" @default.
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- W2024144069 doi "https://doi.org/10.1016/0012-1606(82)90217-2" @default.
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