Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024144538> ?p ?o ?g. }
- W2024144538 endingPage "2218" @default.
- W2024144538 startingPage "2208" @default.
- W2024144538 abstract "So far, the annotation of translation initiation sites (TISs) has been based mostly upon bioinformatics rather than experimental evidence. We adapted ribosomal footprinting to puromycin-treated cells to generate a transcriptome-wide map of TISs in a human monocytic cell line. A neural network was trained on the ribosomal footprints observed at previously annotated AUG translation initiation codons (TICs), and used for the ab initio prediction of TISs in 5062 transcripts with sufficient sequence coverage. Functional interpretation suggested 2994 novel upstream open reading frames (uORFs) in the 5' UTR, 1406 uORFs overlapping with the coding sequence, and 546 N-terminal protein extensions. The TIS detection method was validated on the basis of previously published alternative TISs and uORFs. Among primates, TICs in newly annotated TISs were significantly more conserved than control codons, both for AUGs and near-cognate codons. The transcriptome-wide map of novel candidate TISs derived as part of the study will shed further light on the way in which human proteome diversity is influenced by alternative translation initiation and regulation." @default.
- W2024144538 created "2016-06-24" @default.
- W2024144538 creator A5004473894 @default.
- W2024144538 creator A5007594146 @default.
- W2024144538 creator A5042480855 @default.
- W2024144538 creator A5048156942 @default.
- W2024144538 creator A5052233390 @default.
- W2024144538 creator A5059435501 @default.
- W2024144538 creator A5061462202 @default.
- W2024144538 creator A5066017161 @default.
- W2024144538 creator A5078189933 @default.
- W2024144538 creator A5079734994 @default.
- W2024144538 creator A5089733480 @default.
- W2024144538 date "2012-08-09" @default.
- W2024144538 modified "2023-10-13" @default.
- W2024144538 title "Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting" @default.
- W2024144538 cites W1546420641 @default.
- W2024144538 cites W1771918025 @default.
- W2024144538 cites W1966155870 @default.
- W2024144538 cites W1967812314 @default.
- W2024144538 cites W1971739920 @default.
- W2024144538 cites W1972230095 @default.
- W2024144538 cites W1974670349 @default.
- W2024144538 cites W1977966865 @default.
- W2024144538 cites W1980069210 @default.
- W2024144538 cites W1983637156 @default.
- W2024144538 cites W1986399270 @default.
- W2024144538 cites W1989534797 @default.
- W2024144538 cites W1991065280 @default.
- W2024144538 cites W1991407392 @default.
- W2024144538 cites W1991743074 @default.
- W2024144538 cites W1994244877 @default.
- W2024144538 cites W1999090224 @default.
- W2024144538 cites W2000703421 @default.
- W2024144538 cites W2001510832 @default.
- W2024144538 cites W2006226554 @default.
- W2024144538 cites W2006571365 @default.
- W2024144538 cites W2008086014 @default.
- W2024144538 cites W2012346470 @default.
- W2024144538 cites W2012359139 @default.
- W2024144538 cites W2015803078 @default.
- W2024144538 cites W2016800268 @default.
- W2024144538 cites W2022083392 @default.
- W2024144538 cites W2024644454 @default.
- W2024144538 cites W2025566872 @default.
- W2024144538 cites W2026450727 @default.
- W2024144538 cites W2034195215 @default.
- W2024144538 cites W2036066092 @default.
- W2024144538 cites W2037313242 @default.
- W2024144538 cites W2041760432 @default.
- W2024144538 cites W2044995847 @default.
- W2024144538 cites W2045376151 @default.
- W2024144538 cites W2049528674 @default.
- W2024144538 cites W2052066329 @default.
- W2024144538 cites W2058844028 @default.
- W2024144538 cites W2058977593 @default.
- W2024144538 cites W2063530272 @default.
- W2024144538 cites W2063783857 @default.
- W2024144538 cites W2071849521 @default.
- W2024144538 cites W2079517684 @default.
- W2024144538 cites W2080052447 @default.
- W2024144538 cites W2082047304 @default.
- W2024144538 cites W2083555350 @default.
- W2024144538 cites W2094163526 @default.
- W2024144538 cites W2099273977 @default.
- W2024144538 cites W2099468911 @default.
- W2024144538 cites W2102711634 @default.
- W2024144538 cites W2110132014 @default.
- W2024144538 cites W2112219157 @default.
- W2024144538 cites W2112633314 @default.
- W2024144538 cites W2113286169 @default.
- W2024144538 cites W2119229647 @default.
- W2024144538 cites W2119336718 @default.
- W2024144538 cites W2119634498 @default.
- W2024144538 cites W2123551500 @default.
- W2024144538 cites W2127848114 @default.
- W2024144538 cites W2131814529 @default.
- W2024144538 cites W2133968430 @default.
- W2024144538 cites W2139333251 @default.
- W2024144538 cites W2149424410 @default.
- W2024144538 cites W2152974197 @default.
- W2024144538 cites W2167852161 @default.
- W2024144538 doi "https://doi.org/10.1101/gr.139568.112" @default.
- W2024144538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3483550" @default.
- W2024144538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22879431" @default.
- W2024144538 hasPublicationYear "2012" @default.
- W2024144538 type Work @default.
- W2024144538 sameAs 2024144538 @default.
- W2024144538 citedByCount "194" @default.
- W2024144538 countsByYear W20241445382013 @default.
- W2024144538 countsByYear W20241445382014 @default.
- W2024144538 countsByYear W20241445382015 @default.
- W2024144538 countsByYear W20241445382016 @default.
- W2024144538 countsByYear W20241445382017 @default.
- W2024144538 countsByYear W20241445382018 @default.
- W2024144538 countsByYear W20241445382019 @default.
- W2024144538 countsByYear W20241445382020 @default.
- W2024144538 countsByYear W20241445382021 @default.